{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:27:20Z","timestamp":1783132040735,"version":"3.54.6"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T00:00:00Z","timestamp":1385337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Rigshospitalet Research Committee"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The use of radiotherapy (RT) is debated for pediatric patients with Hodgkin lymphoma (HL) due to the late effects of treatment. Radiation doses to the thyroid, heart, lungs, and breasts are compared with the extensive mantle field (MF), Involved Field RT (IFRT), Modified IFRT (mIFRT), and Involved Node RT (INRT) and the risk of radiation\u2010induced cardiovascular disease, secondary cancers, and the corresponding Life Years Lost (LYL) is estimated with each technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>INRT, mIFRT, IFRT, and MF plans (20 and 30\u2009Gy) were simulated for 10 supradiaphragmatic, clinical stage I\u2013II classical HL patients \u226418 years old, total of 4\u2009\u00d7\u20092 plans for each patient. The lifetime excess risks of cardiac morbidity, cardiac mortality, lung, breast, and thyroid cancer with each technique were estimated. The estimated excess risks attributable to RT were based on HL series with long\u2010term follow\u2010up, treating death from other causes as competing risks. The corresponding LYL were derived from the estimated excess risks. Statistical analyses were performed with repeated measures ANOVA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both a reduction in field size and in prescribed radiation dose significantly lowered the estimated dose to the heart, lungs, breasts, and thyroid compared to past, extended fields, even for patients with mediastinal disease. This translated into a significantly reduced estimated risk of cardiovascular disease, secondary cancers, and LYL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Involved Node Radiotherapy should be considered for pediatric patients with Hodgkin lymphoma since it is estimated to substantially lower the risk of severe long\u2010term complications. Pediatr Blood Cancer 2014;61:717\u2013722. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24861","type":"journal-article","created":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T15:50:57Z","timestamp":1385394657000},"page":"717-722","source":"Crossref","is-referenced-by-count":52,"title":["The impact of involved node, involved field and mantle field radiotherapy on estimated radiation doses and risk of late effects for pediatric patients with Hodgkin lymphoma"],"prefix":"10.1002","volume":"61","author":[{"given":"M.V.","family":"Maraldo","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Oncology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.P.","family":"Brodin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Radiation Oncology Albert Einstein College of Medicine of Yeshiva University Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.","family":"Aznar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Faculty of Sciences Niels Bohr Institute University of Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.R.","family":"Vogelius","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Oncology Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Hematology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.K.","family":"Berthelsen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Clinical Physiology Nuclear Medicine and PET Rigshospitalet, University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.B.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Nuclear Medicine and PET 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