{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:51:07Z","timestamp":1784749867295,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T00:00:00Z","timestamp":1385078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>Lymphangiomas of the tongue are rare, and their treatment is problematic. A 10 year\u2010old patient with tongue lymphangioma who was previously treated with surgery and propranolol with no response was treated with sirolimus in our department. We used sirolimus with a dose of 1.6\u2009mg\/m<jats:sup>2<\/jats:sup>\/day. After 3 months of treatment, the mass had decreased by more than 60%. We continued the treatment for 1 year with a maximum response of 70% decrease in mass. Disease remained stable 6 months after stopping therapy, the latest time of follow\u2010up. Sirolimus appears to be effective in lymphangioma but requires further study. Pediatr Blood Cancer 2014;61:931\u2013932. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24866","type":"journal-article","created":{"date-parts":[[2013,11,23]],"date-time":"2013-11-23T07:54:30Z","timestamp":1385193270000},"page":"931-932","source":"Crossref","is-referenced-by-count":54,"title":["Treatment of a tongue lymphangioma with sirolimus after failure of surgical resection and propranolol"],"prefix":"10.1002","volume":"61","author":[{"given":"Canan","family":"Aky\u00fcz","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology Hacettepe University, Cancer Institute Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erman","family":"Ata\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Hacettepe University, Cancer Institute Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Varan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Hacettepe University, Cancer Institute Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,22]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(97)90062-8"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90743-O"},{"key":"e_1_2_4_4_1","first-page":"159","volume-title":"Developmental disturbances of the tongue. 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