{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:19Z","timestamp":1786978279523,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T00:00:00Z","timestamp":1389052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We sought to improve lumbar spine bone mineral density (LS\u2010BMD) in long\u2010term survivors of childhood acute lymphoblastic leukemia (ALL) using calcium and cholecalciferol supplementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>This double\u2010blind, placebo\u2010controlled trial randomized 275 participants (median age, 17 [9\u201336.1] years) with age\u2010 and gender\u2010specific LS\u2010BMD Z\u2010scores &lt;0 to receive nutritional counseling with supplementation of 1,000\u2009mg\/day calcium and 800\u2009International Unit cholecalciferol or placebo for 2 years. The primary outcome was change in LS\u2010BMD assessed by quantitative computerized tomography (QCT) at 24 months. Linear regression models were employed to identify the baseline risk factors for low LS\u2010BMD and to compare LS\u2010BMD outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pre\u2010randomization LS\u2010BMD below the mean was associated with male gender (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0024), White race (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0003), lower body mass index (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001), and cumulative glucocorticoid doses of \u22655,000\u2009mg (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0012). One hundred eighty\u2010eight (68%) participants completed the study; 77% adhered to the intervention. Mean LS\u2010BMD change did not differ between survivors randomized to supplements (0.33\u2009\u00b1\u20090.57) or placebo (0.28\u2009\u00b1\u20090.56). Participants aged 9\u201313 years and those 22\u201335 years had the greatest mean increases in LS\u2010BMD (0.50\u2009\u00b1\u20090.66 and 0.37\u2009\u00b1\u20090.23, respectively). Vitamin D insufficiency (serum 25[OH]D &lt;30\u2009ng\/ml) found in 296 (75%), was not associated with LS\u2010BMD outcomes (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.78).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cholecalciferol and calcium supplementation provides no added benefit to nutritional counseling for improving LS\u2010BMD among adolescent and young adult survivors of ALL (93% of whom had LS\u2010BMD Z\u2010scores above the mean at study entry). Pediatr Blood Cancer 2014;61:885\u2013893. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.24882","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T03:54:43Z","timestamp":1389066883000},"page":"885-893","source":"Crossref","is-referenced-by-count":41,"title":["Calcium and cholecalciferol supplementation provides no added benefit to nutritional counseling to improve bone mineral density in survivors of childhood acute lymphoblastic leukemia (ALL)"],"prefix":"10.1002","volume":"61","author":[{"given":"S.C.","family":"Kaste","sequence":"first","affiliation":[{"name":"St. Jude Children's Research Hospital Memphis Tennessee"},{"name":"University of Tennessee Health Science Center Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Qi","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital Memphis 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