{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:16:46Z","timestamp":1761513406062,"version":"3.37.3"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T00:00:00Z","timestamp":1389916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Eunice Kennedy Shriver National Institute of Child Health & Human Development:","award":["5R01HD062347-01"],"award-info":[{"award-number":["5R01HD062347-01"]}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute:","doi-asserted-by":"crossref","award":["1R01HL103427-01A1"],"award-info":[{"award-number":["1R01HL103427-01A1"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"name":"EMSC:","award":["U03MC00001, U03MC00003, U03MC00006, U03MC00007, U03MC00008, U03MC22684, U03MC22685"],"award-info":[{"award-number":["U03MC00001, U03MC00003, U03MC00006, U03MC00007, U03MC00008, U03MC22684, U03MC22685"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Multiple recent Sickle Cell Disease studies have been terminated due to poor enrollment. We developed methods to overcome past barriers and utilized these to study the efficacy and safety of intravenous magnesium for vaso\u2010occlusive crisis (VOC). We describe the methods of the Intravenous Magnesium in Sickle Vaso\u2010occlusive Crisis (MAGiC) trial and discuss methods used to overcome past barriers. MAGiC was a multi\u2010center randomized double\u2010blind placebo\u2010controlled trial of intravenous magnesium versus normal saline for treatment of VOC. The study was a collaboration between Pediatric Hematologists and Emergency Physicians in the Pediatric Emergency Care Applied Research Network (PECARN). Eligible patients were randomized within 12\u2009hours of receiving intravenous opioids in the Emergency Department (ED) and administered study medication every 8\u2009hours. The primary outcome was hospital length of stay. Associated plasma studies elucidated magnesium's mechanism of action and the pathophysiology of VOC. Health\u2010related quality of life was measured. Site\u2010, protocol\u2010, and patient\u2010related barriers from prior studies were identified and addressed. Limited study staff availability, lack of collaboration with the ED, and difficulty obtaining consent were previously identified barriers. Leveraging PECARN resources, forging close collaborations between Sickle Cell Centers and EDs of participating sites, and approaching eligible patients for prior consent helped overcome these barriers. Participation in the PECARN network and establishment of collaborative arrangements between Sickle Cell Centers and their affiliated EDs are major innovative features of the MAGiC study that allowed improved subject capture. These methods could serve as a model for future studies of VOCs. Pediatr Blood Cancer 2014;61:1049\u20131054. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24925","type":"journal-article","created":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T14:42:47Z","timestamp":1389969767000},"page":"1049-1054","source":"Crossref","is-referenced-by-count":21,"title":["Intravenous magnesium for pediatric sickle cell vaso\u2010occlusive crisis: Methodological issues of a randomized controlled trial"],"prefix":"10.1002","volume":"61","author":[{"given":"Oluwakemi","family":"Badaki\u2010Makun","sequence":"first","affiliation":[{"name":"Department of Pediatrics Emergency Medicine and Trauma Center Children's National Medical Center Washington District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Paul","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hematology\/Oncology\/Bone Marrow Transplant Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Panepinto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hematology\/Oncology\/Bone Marrow Transplant Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Charles","family":"Casper","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl A.","family":"Hillery","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hematology\/Oncology\/Bone Marrow Transplant Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Michael","family":"Dean","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Brousseau","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Emergency Medicine Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Pediatric Emergency Care Applied Research Network (PECARN) Magnesium in Sickle Cell Crisis (MAGiC) Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61029-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23145"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05622.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199107043250103"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20180"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.378"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606193142501"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807023390102"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07097.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029609352661"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e31815a05e2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328329e167"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003350.pub2"},{"key":"e_1_2_6_15_1","unstructured":"1999 American Pain Society LJ Benjamin CD Dampier A Jacox Guideline for the management of acute and chronic pain in sickle\u2010cell disease"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.235"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09105.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2011.11.018"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1740774513475850"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08827.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24486"},{"key":"e_1_2_6_22_1","unstructured":"National Institutes of Health.Clinicaltrials.gov.http:\/\/www.clinicaltrials.gov\/ct2\/results?term=sickle+cell+&Search=Search. 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