{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:32:34Z","timestamp":1790703154447,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Testicular dysfunction and infertility are of major concern in long\u2010term survivors after allogeneic hematopoietic stem cell transplantation (HSCT). This study assesses predictive factors for very long\u2010term testicular recovery after allogeneic HSCT in childhood and adolescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Testicular volume, sperm production and long\u2010term need of testosterone substitution were evaluated among 106 male survivors transplanted at Huddinge and Helsinki University Hospitals from 1978 through 2000, at a mean age of 8\u2009\u00b1\u20094.6 years (range 1\u201317). A mean\u2009\u00b1\u2009SD of 13\u2009\u00b1\u20094.8 years (range 4\u201328) had elapsed since their HSCT and the mean age of the participants was 22\u2009\u00b1\u20096.0 years (range 12\u201342). An adult testicular volume was recorded in 74 patients at a mean age of 19\u2009\u00b1\u20093.3 years (range 14\u201336).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recipients conditioned with busulfan\u2010based regimens or regimens containing only cyclophosphamide had significantly larger adult testicular volumes (mean volume 18\u2009ml and 16\u2009ml vs. 9\u2009ml, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.00001, respectively) and lower serum levels of FSH (mean 9\u2009IU and 5\u2009IU vs. 19\u2009IU, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01 and 0.001, respectively) compared to those conditioned with total body irradiation (TBI). Multivariate analysis demonstrated that a non\u2010leukemia diagnosis (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and adult testicular volume \u226515\u2009ml (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.03) positively impacted spermatogenetic recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A larger adult testicular volume, normal serum levels of FSH and spermatozoa detected in a majority of seminal fluids after busulfan\u2010based or cyclophosphamide conditionings suggest very long\u2010term recovery of spermatogenesis after chemotherapy\u2010based regimens. A simple measurement of adult testicular volume may help predict spermatogenetic potential among pediatric HSCT survivors. Pediatr Blood Cancer 2014;61:1094\u20131100. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.24970","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T11:38:56Z","timestamp":1392205136000},"page":"1094-1100","source":"Crossref","is-referenced-by-count":40,"title":["Adult testicular volume predicts spermatogenetic recovery after allogeneic HSCT in childhood and adolescence"],"prefix":"10.1002","volume":"61","author":[{"given":"Mari","family":"Wilhelmsson","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden"},{"name":"Department of Pediatrics Astrid Lindgren Children's Hospital, Karolinska University Hospital Huddinge Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Vatanen","sequence":"additional","affiliation":[{"name":"Division of Haematology\u2010Oncology and Stem Cell Transplantation Children's Hospital, University of Helsinki, Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Borgstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Astrid Lindgren Children's Hospital, Karolinska University Hospital Huddinge Stockholm Sweden"},{"name":"Department of Clinical Science Intervention, and Technology, Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Astrid Lindgren Children's Hospital, Karolinska University Hospital Huddinge Stockholm Sweden"},{"name":"Department of Clinical Science Intervention, and Technology, Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervi","family":"Taskinen","sequence":"additional","affiliation":[{"name":"Division of 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