{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:51:31Z","timestamp":1790488291267,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To assess the feasibility and effectiveness of high\u2010dose chemotherapy (HDC) with stem cell support followed by conventional craniospinal radiotherapy (RT) as treatment for children older than 5 years of age with newly diagnosed high\u2010risk medulloblastoma (MB) or supratentorial PNET (sPNET).<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Between May 2001 and April 2010, 24 children older than 5 years of age (MB\u2009=\u200921; sPNET\u2009=\u20093), fulfilling inclusion criteria at diagnosis, were treated at Gustave Roussy. After conventional chemotherapy, they received two courses of high\u2010dose thiotepa (600\u2009mg\/m<jats:sup>2<\/jats:sup>) followed by craniospinal RT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up was 4.4 years (range, 0.8\u201311.3 years). For children with metastatic MB, the 5\u2010year event\u2010free survival (EFS) and overall survival (OS) were 72% and 83%, respectively. The toxicity was manageable. No toxic death occurred. At the most recent evaluation, among the 24 children who had at least one Full Scale Intellectual Quotient (FSIQ) examination at a median follow\u2010up of 3.79 years after diagnosis, the mean estimated FSIQ was 82 (range, 56\u2013114).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In children with metastatic MB, tandem HDCT with ASCT followed by conventional craniospinal RT proved its feasibility without jeopardizing survival. Pediatr Blood Cancer 2014; 61:1398\u20131402. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25009","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T03:20:24Z","timestamp":1395717624000},"page":"1398-1402","source":"Crossref","is-referenced-by-count":58,"title":["Tandem high\u2010dose chemotherapy and autologous stem cell rescue in children with newly diagnosed high\u2010risk medulloblastoma or supratentorial primitive neuro\u2010ectodermic tumors"],"prefix":"10.1002","volume":"61","author":[{"given":"Christelle","family":"Dufour","sequence":"first","affiliation":[{"name":"Department of Pediatric and Adolescent Oncology Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Kieffer","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Oncology Gustave Roussy Villejuif France"},{"name":"Physical Medicine and Rehabilitation Department for Children With Acquired Neurological Injuries H\u00f4pital National de Saint Maurice Saint\u2010Maurice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Varlet","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Sainte\u2010Anne Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Anne","family":"Raquin","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Oncology Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Dhermain","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Puget","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Necker\u2010Enfants Malades Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Valteau\u2010Couanet","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Oncology Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Grill","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Oncology Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(04)01424-X"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880515)61:10<1992::AID-CNCR2820611011>3.0.CO;2-J"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1994.81.5.0690"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.10.2696"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.02.026"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.3.832"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.12.126"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70867-1"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70872-5"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0243-4"},{"key":"e_1_2_5_12_1","first-page":"312","article-title":"Preoperative chemotherapy in children with high\u2010risk medulloblastomas: A feasibility study","volume":"103","author":"Grill J","year":"2005","journal-title":"J Neurosurg"},{"key":"e_1_2_5_13_1","unstructured":"RiccardiR CefaloG RuggieroA et al. editors.Antitumor activity of temozolomide in medulloblastoma\u2014PNET. 12th international symposium on pediatric neuro\u2010oncology; 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