{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:18:08Z","timestamp":1788369488351,"version":"build-2803163510"},"reference-count":6,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:00:00Z","timestamp":1398038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Hyperferritinemia is a hallmark of hemophagocytic lymphohistiocytosis (HLH). In the HLH\u20102004 criteria, a ferritin value &gt;500\u2009\u00b5g\/L is considered positive. However, this level was not determined based on evidence. We compared 123 patients with HLH and 320 patients with other hyperferritinemic conditions, calculated a receiver\u2010operating characteristic, and determined sensitivity and specificity for different values. At 2,000\u2009\u00b5g\/L a trade\u2010off is reached with sensitivity at 70% and specificity at 68%. If familial HLH and virus\u2010associated acquired HLH are analyzed separately, sensitivity and specificity are similar for this level. The results may guide a potential modification of the current HLH criteria. Pediatr Blood Cancer 2014;61:2101\u20132103. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.25058","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T11:02:45Z","timestamp":1398078165000},"page":"2101-2103","source":"Crossref","is-referenced-by-count":84,"title":["Determination of an appropriate cut\u2010off value for ferritin in the diagnosis of hemophagocytic lymphohistiocytosis"],"prefix":"10.1002","volume":"61","author":[{"given":"Kai","family":"Lehmberg","sequence":"first","affiliation":[{"name":"Pediatric Hematology and Oncology University Hospital Medical Center Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth L.","family":"McClain","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine Texas Children's Hospital Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gritta E.","family":"Janka","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology University Hospital Medical Center Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl E.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine Texas Children's Hospital Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-278127"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21423"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.11.081"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/39.4.561"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e31829ce01f"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25058","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25058","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.25058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:21:39Z","timestamp":1696465299000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.25058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,21]]},"references-count":6,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1002\/pbc.25058"],"URL":"https:\/\/doi.org\/10.1002\/pbc.25058","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,21]]}}}