{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:23:52Z","timestamp":1778084632437,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T00:00:00Z","timestamp":1398211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T00:00:00Z","timestamp":1398211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Blood Cancer"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1002\/pbc.25077","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T08:02:44Z","timestamp":1398240164000},"page":"1593-1597","source":"Crossref","is-referenced-by-count":13,"title":["Is multifocality a prognostic factor in childhood hepatoblastoma?"],"prefix":"10.1002","volume":"61","author":[{"given":"Francesco","family":"Saettini","sequence":"first","affiliation":[{"name":"Department of Pediatrics; University of Milano-Bicocca; San Gerardo Hospital; Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentino","family":"Conter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; University of Milano-Bicocca; San Gerardo Hospital; Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Provenzi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Ospedale Papa Giovanni XXIII; Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Rota","sequence":"additional","affiliation":[{"name":"Department of Health Sciences; Centre of Biostatistics for Clinical Epidemiology; University of Milano-Bicocca; Monza Italy"},{"name":"Department of Epidemiology; Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d-IRCSS; Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Giraldi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Ospedale Papa Giovanni XXIII; Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Foglia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Ospedale Papa Giovanni XXIII; Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Cavalleri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Ospedale Papa Giovanni XXIII; Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"D'Antiga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Ospedale Papa Giovanni XXIII; Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,23]]},"reference":[{"key":"10.1002\/pbc.25077-BIB0001|pbc25077-cit-0001","first-page":"847","volume-title":"Principles and practice of pediatric oncology","author":"Pizzo","year":"2006"},{"key":"10.1002\/pbc.25077-BIB0002|pbc25077-cit-0002","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1200\/JCO.2000.18.22.3819","article-title":"Cisplatin, doxorubicin, and delayed surgery for childhood hepatoblastoma: A successful approach-results of the first prospective study of the International Society of Pediatric Oncology","volume":"18","author":"Pritchard","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1002\/pbc.25077-BIB0003|pbc25077-cit-0003","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ejca.2003.06.003","article-title":"International Society of Paediatric Oncology-SIOPEL 2. Risk-adapted treatment for childhood hepatoblastoma. Final report of the second study of the International Society of Paediatric Oncology-SIOPEL 2","volume":"40","author":"Perilongo","year":"2004","journal-title":"Eur J Cancer"},{"key":"10.1002\/pbc.25077-BIB0004|pbc25077-cit-0004","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1200\/JCO.2009.22.4857","article-title":"Successful treatment of childhood high-risk hepatoblastoma with dose-intensive multiagent chemotherapy and surgery: Final results of the SIOPEL-3HR study","volume":"28","author":"Zs\u00edros","journal-title":"J Clin Oncol"},{"key":"10.1002\/pbc.25077-BIB0005|pbc25077-cit-0005","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1056\/NEJMoa0810613","article-title":"Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma","volume":"361","author":"Perilongo","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1002\/pbc.25077-BIB0006|pbc25077-cit-0006","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1200\/JCO.2005.07.145","article-title":"Predictive value of the pretreatment extent of disease system in hepatoblastoma: Results from the International Society of Pediatric Oncology Liver Tumor Study Group SIOPEL-1 study","volume":"23","author":"Aronson","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1002\/pbc.25077-BIB0007|pbc25077-cit-0007","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.ejca.2011.12.011","article-title":"Prognostic stratification for children with hepatoblastoma: The SIOPEL experience","volume":"48","author":"Maibach","year":"2012","journal-title":"Eur J Cancer"},{"key":"10.1002\/pbc.25077-BIB0008|pbc25077-cit-0008","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jpedsurg.2009.10.023","article-title":"Defining hepatoblastoma responsiveness to induction therapy as measured by tumor volume and serum \u03b1-fetoprotein kinetics","volume":"45","author":"Lovvorn","year":"2010","journal-title":"J Pediatr Surg"},{"key":"10.1002\/pbc.25077-BIB0009|pbc25077-cit-0009","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0022-3476(98)70008-3","article-title":"Risk of cancer during the first four years in life of children from Beckwith-Wiedemann Syndrome Registry","volume":"132","author":"DeBaun","year":"1998","journal-title":"J Pediatr"},{"key":"10.1002\/pbc.25077-BIB0010|pbc25077-cit-0010","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/pbc.24219","article-title":"Chemotherapeutic approaches for newly diagnosed hepatoblastoma: Past, present, and future strategies","volume":"59","author":"Trobaugh-Lotrario","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"10.1002\/pbc.25077-BIB0011|pbc25077-cit-0011","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.2741\/e492","article-title":"Treatment of hepatoblastoma: The North American cooperative group experience","volume":"4","author":"Malogolowkin","year":"2012","journal-title":"Front Biosci"},{"key":"10.1002\/pbc.25077-BIB0012|pbc25077-cit-0012","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/pbc.10376","article-title":"Liver transplantation for hepatoblastoma: Results from the International Society of Pediatric Oncology (SIOP) study SIOPEL-1 and review of the world experience","volume":"42","author":"Otte","year":"2004","journal-title":"Pediatr Blood Cancer"},{"key":"10.1002\/pbc.25077-BIB0013|pbc25077-cit-0013","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.ejca.2005.02.004","article-title":"Guidelines for surgical treatment of hepatoblastoma in the modern era-recommendations from the Childhood Liver Tumour Strategy Group of the International Society of Paediatric Oncology (SIOPEL)","volume":"41","author":"Czauderna","year":"2005","journal-title":"Eur J Cancer"},{"key":"10.1002\/pbc.25077-BIB0014|pbc25077-cit-0014","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/cncr.22876","article-title":"Features predicting unresectability in hepatoblastoma","volume":"110","author":"D'Antiga","year":"2007","journal-title":"Cancer"},{"key":"10.1002\/pbc.25077-BIB0015|pbc25077-cit-0015","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.ejca.2005.02.004","article-title":"Guidelines for surgical treatment of hepatoblastoma in the modern era-Recommendations from the Childhood Liver Tumour Strategy Group of the International Society of Paediatric Oncology (SIOPEL)","volume":"41","author":"Czauderna","year":"2005","journal-title":"Eur J Cancer"},{"key":"10.1002\/pbc.25077-BIB0016|pbc25077-cit-0016","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/mpo.10107","article-title":"Multifocal hepatoblastoma: Is there a place for partial hepatectomy","volume":"40","author":"Dall'Igna","year":"2003","journal-title":"Med Pediatr Oncol"},{"key":"10.1002\/pbc.25077-BIB0017|pbc25077-cit-0017","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.ejca.2012.10.003","article-title":"Relapses in hepatoblastoma patients: Clinical characteristics and outcome-Experience of the International Childhood Liver Tumour Strategy Group (SIOPEL)","volume":"49","author":"Semeraro","year":"2013","journal-title":"Eur J Cancer"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25077","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/pbc.25077\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T09:54:09Z","timestamp":1596102849000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/pbc.25077"}},"subtitle":["Multifocality in Childhood Hepatoblastoma"],"short-title":[],"issued":{"date-parts":[[2014,4,23]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"URL":"https:\/\/doi.org\/10.1002\/pbc.25077","archive":["Portico"],"relation":{},"ISSN":["1545-5009"],"issn-type":[{"value":"1545-5009","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4,23]]}}}