{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:23:46Z","timestamp":1790799826690,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,6,29]],"date-time":"2014-06-29T00:00:00Z","timestamp":1404000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The antineoplastic agents cisplatin and carboplatin are widely\u2010used and highly\u2010effective against a variety of pediatric cancers. Unfortunately, ototoxicity is a frequently encountered side effect of platinum\u2010based chemotherapy. There is currently no treatment or prevention for platinum\u2010induced ototoxicity and development of hearing loss may lead to devastating consequences on the quality of life of pediatric cancer survivors. The objective of this study is to determine the incidence of platinum\u2010induced ototoxicity in a large series of pediatric patients and to evaluate the incidence of progression of ototoxicity after completion of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>A retrospective chart review of pediatric patients treated with cisplatin or carboplatin between 2000 and 2012 was conducted. The incidence of ototoxicity was determined based on the American\u2010Speech\u2010Language\u2010Hearing Association (ASHA) criteria and severity was based on the Chang classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred and sixty\u2010six patients received platinum\u2010based chemotherapy. Patients were excluded due to congenital hearing loss (n\u2009=\u20091) and insufficient data for calculating the platinum dose (n\u2009=\u200924) or for assessing ototoxicity (n\u2009=\u2009135). Three hundred and six patients were included in the analysis. Post\u2010chemotherapy ototoxicity was detected in 148 (48%) patients, and clinically\u2010significant ototoxicity was present in 91 (30%). In addition, based on the ASHA criteria, 48% of patients (97\/204) with long\u2010term follow\u2010up had further deterioration of their hearing after completion of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ototoxicity following chemotherapy with cisplatin or carboplatin is common and can frequently progress after the completion of treatment. Long\u2010term follow\u2010up is strongly recommended. Pediatr Blood Cancer 2014;61:2012\u20132017. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25123","type":"journal-article","created":{"date-parts":[[2014,6,29]],"date-time":"2014-06-29T18:53:18Z","timestamp":1404067998000},"page":"2012-2017","source":"Crossref","is-referenced-by-count":48,"title":["Incidence of platinum\u2010induced ototoxicity in pediatric patients in Quebec"],"prefix":"10.1002","volume":"61","author":[{"given":"Emilia","family":"Peleva","sequence":"first","affiliation":[{"name":"McGill Auditory Sciences Laboratory McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Emami","sequence":"additional","affiliation":[{"name":"McGill Auditory Sciences Laboratory McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0306-3256","authenticated-orcid":false,"given":"Mohammad","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"McGill Auditory Sciences Laboratory McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aren","family":"Bezdjian","sequence":"additional","affiliation":[{"name":"McGill Auditory Sciences Laboratory McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Gurberg","sequence":"additional","affiliation":[{"name":"McGill Auditory Sciences Laboratory McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Sophie","family":"Carret","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\u2010Oncology CHU Sainte\u2010Justine\/Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam J.","family":"Daniel","sequence":"additional","affiliation":[{"name":"McGill Auditory Sciences Laboratory McGill University Montreal Quebec Canada"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Montreal Children's Hospital Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.219.177"},{"key":"e_1_2_7_3_1","volume-title":"Pharmacology and ototoxicity for audiologists","author":"Campbell KCM","year":"2007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.09.015"},{"key":"e_1_2_7_5_1","first-page":"CD009219","article-title":"Medical interventions for the prevention of platinum\u2010induced hearing loss in children with cancer","volume":"5","author":"van As JW","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21898"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31815d1d83"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-010-0136-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181cb8593"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/14992027.2010.485595"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23275"},{"key":"e_1_2_7_13_1","unstructured":"American Speech\u2010Language\u2010Hearing Association (ASHA).Audiologic management of individuals receiving cochleotoxic drug therapy [Guidelines].http:\/\/www.asha.org\/policy\/GL1994\u20130000 3\/. 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