{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:22:14Z","timestamp":1788474134129,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T00:00:00Z","timestamp":1405382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["R01 CA111355"],"award-info":[{"award-number":["R01 CA111355"]}]},{"name":"NIH","award":["T32 CA099936"],"award-info":[{"award-number":["T32 CA099936"]}]},{"name":"NIH","award":["K05 CA157439"],"award-info":[{"award-number":["K05 CA157439"]}]},{"name":"Macy Easom Fund for Childhood Cancer Research"},{"name":"Children's Cancer Research Fund, Minneapolis, MN"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatoblastoma is a malignancy of young children. Low birth weight is associated with significantly increased risk of hepatoblastoma and neonatal medical exposures are hypothesized as contributors. This study represents the largest case\u2013control study of hepatoblastoma to date and aimed to define the role of neonatal exposures in hepatoblastoma risk among low birth weight children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Incident hepatoblastoma cases who were born &lt;2,500\u2009g (N\u2009=\u200960), diagnosed between 2000 and 2008, were identified through the Children's Oncology Group. Controls were recruited through state birth registries (N\u2009=\u200951). Neonatal medical exposures were abstracted from medical records. Subjects from the Vermont Oxford Network were used for further comparisons, as were existing reports on neonatal medical exposures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Case\u2013control comparisons were hindered by poor matching within birth weight strata. Cases were smaller and received more aggressive neonatal treatment compared to controls, and reflected high correlation levels between birth weight and treatments. Similar difficulty was encountered when comparing cases to Vermont Oxford Network subjects; cases were smaller and required more aggressive neonatal therapy. Furthermore, it appears hepatoblastoma cases were exposed to a greater number of diagnostic X\u2010rays than in case series previously reported in the neonatal literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study presents the largest case series of hepatoblastoma in &lt;2,500\u2009g birth weight infants with accompanying neonatal medical exposure data. Findings confirm that birth weight is highly correlated with exposure intensity, and neonatal exposures are themselves highly correlated, which hampers the identification of a causal exposure among hepatoblastoma cases. Experimental models or genetic susceptibility testing may be more revealing of etiology. Pediatr Blood Cancer 2014;61:2018\u20132023. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25128","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T02:00:59Z","timestamp":1405476059000},"page":"2018-2023","source":"Crossref","is-referenced-by-count":44,"title":["Neonatal medical exposures and characteristics of low birth weight hepatoblastoma cases: A report from the Children's Oncology Group"],"prefix":"10.1002","volume":"61","author":[{"given":"Lucie M.","family":"Turcotte","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Georgieff","sequence":"additional","affiliation":[{"name":"Division of Neonatology University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Ross","sequence":"additional","affiliation":[{"name":"Division of Pediatric Epidemiology and Clinical Research University of Minnesota Minneapolis Minnesota"},{"name":"University of Minnesota Masonic Cancer Center Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Feusner","sequence":"additional","affiliation":[{"name":"Children's Hospital &amp; Research Center Oakland Oakland California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail E.","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center San Antonio Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio H.","family":"Malogolowkin","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology\/Bone Marrow Transplant Children's Hospital of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Krailo","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of the University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Miller","sequence":"additional","affiliation":[{"name":"Division of Neonatology University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Fonstad","sequence":"additional","affiliation":[{"name":"Division of Pediatric Epidemiology and Clinical Research University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan G.","family":"Spector","sequence":"additional","affiliation":[{"name":"Division of Pediatric Epidemiology and Clinical Research University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,15]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"HowladerN NooneAM KrapchoM et al. editors.SEER Cancer Statistics Review 1975\u20132009 (Vintage 2009 Populations) National Cancer Institute Bethesda MD http:\/\/seer.cancer.gov\/csr\/1975_2009_pops09\/ based on November 2011 SEER data submission posted to the SEER web site April 2012. 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