{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:50:27Z","timestamp":1740138627200,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,8,17]],"date-time":"2014-08-17T00:00:00Z","timestamp":1408233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Restrictive lung disease is a complication in childhood cancer survivors who received lung\u2010toxic chemotherapy and\/or thoracic radiation. Left ventricular dysfunction is documented in these survivors, but less is known about right ventricular (RV) function. Quantitative echocardiography may help detect subclinical RV dysfunction. The aim of this study was to assess RV function quantitatively in childhood cancer survivors after lung\u2010toxic therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>We identified records of 33 childhood cancer survivors who (1) were treated with lung\u2010toxic therapy and\/or radiation, (2) were cancer\u2010free for \u2265 one year after therapy, and (3) had pulmonary function tests and echocardiograms from their most recent follow\u2010up visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants' mean age was 11.6\u2009\u00b1\u20094.5 years at cancer diagnosis and 23\u2009\u00b1\u20098.6 years at evaluation. The most common diagnosis was lymphoma\/leukemia (n\u2009=\u200927). Twenty\u2010nine subjects had anthracycline exposure. Eleven of the 33 subjects demonstrated restrictive pulmonary impairment (total lung capacity 3.69\u2009\u00b1\u20091.5 L [69.3\u2009\u00b1\u200922.4% predicted]). Among quantitative measures of RV function, isovolumetric acceleration (IVA), a measure of contractility, was significantly lower in the group with restrictive lung disease (2.42\u2009\u00b1\u20090.56 vs. 1.83\u2009\u00b1\u20090.78\u2009m\/sec<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). There was a trend towards lower tissue Doppler derived S' and tricuspid annular plane systolic excursion in the group with restrictive lung disease. Subjects with restrictive lung disease were found to have \u2265 2 abnormal parameters (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IVA may detect early RV dysfunction in childhood cancer survivors with restrictive lung disease. Our findings require confirmation in a larger study population and validation by cardiac MRI. Pediatr Blood Cancer 2014;61:2059\u20132064. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25157","type":"journal-article","created":{"date-parts":[[2014,8,18]],"date-time":"2014-08-18T03:15:59Z","timestamp":1408331759000},"page":"2059-2064","source":"Crossref","is-referenced-by-count":3,"title":["Association between right ventricular dysfunction and restrictive lung disease in childhood cancer survivors as measured by quantitative echocardiography"],"prefix":"10.1002","volume":"61","author":[{"given":"Amee","family":"Patel","sequence":"first","affiliation":[{"name":"Section of Pediatric Respiratory Medicine Yale University School of Medicine New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance","family":"Weismann","sequence":"additional","affiliation":[{"name":"Section of Pediatric Cardiology Yale University School of Medicine New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pnina","family":"Weiss","sequence":"additional","affiliation":[{"name":"Section of Pediatric Respiratory Medicine Yale University School of Medicine New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry","family":"Russell","sequence":"additional","affiliation":[{"name":"Section of Cardiology Yale University School of Medicine New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0457-7088","authenticated-orcid":false,"given":"Alia","family":"Bazzy\u2010Asaad","sequence":"additional","affiliation":[{"name":"Section of Pediatric Respiratory Medicine Yale University School of Medicine New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina S.","family":"Kadan\u2010Lottick","sequence":"additional","affiliation":[{"name":"Section of Pediatric Hematology\u2010Oncology Yale University School of Medicine and Yale Cancer Center New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn310"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23281"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200618"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685206"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.0702"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.15.1788"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.632208"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.03.018"},{"key":"e_1_2_6_10_1","first-page":"245","volume-title":"Myocardial Imaging: Tissue Doppler and Speckle Tracking","author":"Bleeker G","year":"2007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.082503"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.579268"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.01.016"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-8-3"},{"key":"e_1_2_6_15_1","first-page":"1436","article-title":"Right ventricular function in cardiovascular disease","volume":"117","author":"Haddad F","year":"2008","journal-title":"Part I: Anatomy, Physiology, Aging, and Functional Assessment of the Right Ventricle. 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