{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:13:40Z","timestamp":1784693620961,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,8,17]],"date-time":"2014-08-17T00:00:00Z","timestamp":1408233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:label\/><jats:p>We investigated the association of <jats:italic>VEGFA<\/jats:italic> \u2212583C\u2009&gt;\u2009T on VEGF serum levels and acute chest syndrome (ACS) in 351 pediatric patients with sickle cell disease (SCD), of whom 90 had ACS, and 261 were ACS\u2010free controls. Significant differences in \u2212583C\u2009&gt;\u2009T minor allele and genotype frequencies were seen between ACS cases and controls, evidenced by enrichment of \u2212583T\/T genotypes in patients with ACS, which were linked with reduction in VEGF serum levels. <jats:italic>VEGFA<\/jats:italic> \u2212583C\u2009&gt;\u2009T and reduced VEGF serum levels may influence ACS risk in patients with SCD, which will aid in identifying patients with SCD who are at high risk of ACS. Pediatr Blood Cancer 2014;61:2310\u20132312. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25158","type":"journal-article","created":{"date-parts":[[2014,8,18]],"date-time":"2014-08-18T00:58:59Z","timestamp":1408323539000},"page":"2310-2312","source":"Crossref","is-referenced-by-count":12,"title":["Impact of <i>VEGFA<\/i> \u2212583C\u2009&gt;\u2009T polymorphism on serum VEGF levels and the susceptibility to acute chest syndrome in pediatric patients with sickle cell disease"],"prefix":"10.1002","volume":"61","author":[{"given":"Noor A.","family":"Redha","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry Arabian Gulf University Manama Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najat","family":"Mahdi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Salmaniya Medical Complex Manama Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebah H.","family":"Al\u2010Habboubi","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Arabian Gulf University Manama Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassim Y.","family":"Almawi","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Arabian Gulf University Manama Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,17]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1182\/blood.V84.2.643.643","article-title":"The acute chest syndrome in sickle cell disease: incidence and risk factors.The cooperative study of sickle cell disease","volume":"84","author":"Castro O","year":"1994","journal-title":"Blood"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.066670"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006223422502"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/1119-3077.106774"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006452"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-13213"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2000.0692"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.01.240"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12003"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-012-0317-9"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/359843a0"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1868-7083-5-6"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016982"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.03.010"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)99049-6"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25158","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.25158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:45:58Z","timestamp":1696340758000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.25158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,17]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1002\/pbc.25158"],"URL":"https:\/\/doi.org\/10.1002\/pbc.25158","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,17]]}}}