{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:43:55Z","timestamp":1782272635800,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,8,23]],"date-time":"2014-08-23T00:00:00Z","timestamp":1408752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:label\/><jats:p>The authors describe two young brothers and a 12\u2010year\u2010old male with long\u2010standing thrombocytopenia with normal sized platelets, in whom novel mutations of the WAS gene were identified. Their clinical picture and the in vitro assessment of the T\u2010cell function were consistent with X\u2010linked thrombocytopenia (XLT). A high index of suspicion for XLT is required, even in the setting of normal sized platelets for males with affected maternally\u2010related male family members, and males with moderately severe chronic thrombocytopenia that have failed to respond to treatments that are usually effective for immune thrombocytopenia. Pediatr Blood Cancer 2014;61:2305\u20132306. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25196","type":"journal-article","created":{"date-parts":[[2014,8,23]],"date-time":"2014-08-23T21:37:56Z","timestamp":1408829876000},"page":"2305-2306","source":"Crossref","is-referenced-by-count":13,"title":["X\u2010linked thrombocytopenia in three males with normal sized platelets due to novel <i>WAS<\/i> gene mutations"],"prefix":"10.1002","volume":"61","author":[{"given":"Elpis","family":"Mantadakis","sequence":"first","affiliation":[{"name":"Department of Pediatrics Democritus University of Thrace Faculty of Medicine Alexandroupolis Thrace Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Sawalle\u2010Belohradsky","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Dr von Haunersches Kinderspital Ludwig\u2010Maximilians\u2010Universit\u00e4t Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Tzanoudaki","sequence":"additional","affiliation":[{"name":"Department of Immunology and Histocompatibility Specialized &amp; Referral Centre for Primary Immunodeficiencies\u2010Pediatric Immunology \u201cAghia Sophia\u201d Children's Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kanariou","sequence":"additional","affiliation":[{"name":"Department of Immunology and Histocompatibility Specialized &amp; Referral Centre for Primary Immunodeficiencies\u2010Pediatric Immunology \u201cAghia Sophia\u201d Children's Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanassios","family":"Chatzimichael","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Democritus University of Thrace Faculty of Medicine Alexandroupolis Thrace Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Albert","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Dr von Haunersches Kinderspital Ludwig\u2010Maximilians\u2010Universit\u00e4t Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12049"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.11-RAI-0412"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-319376"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-115253"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32834114bc"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3282f30448"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.10.007"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(01)00549-X"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.2.509"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V65.6.1439.bloodjournal6561439"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22920"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V55.2.243.243"},{"key":"e_1_2_5_14_1","first-page":"190","article-title":"Chickenpox\u2010associated immune thrombocytopenic purpura","volume":"15","author":"Mantadakis E","year":"2011","journal-title":"Hippokratia"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-239087"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1739"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200312000-00003"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.7.2680"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25196","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.25196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:45:29Z","timestamp":1696340729000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.25196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,23]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1002\/pbc.25196"],"URL":"https:\/\/doi.org\/10.1002\/pbc.25196","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,23]]}}}