{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:23:27Z","timestamp":1775780607450,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T00:00:00Z","timestamp":1411776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Allogeneic hematopoietic stem cell transplantation (AHSCT) represents the only curative treatment for the majority of pediatric patients with Myelodysplastic Syndrome (MDS). We aimed to evaluate overall survival (OS), disease\u2010free survival (DFS), non\u2010relapse mortality (NRM) and relapse incidence in children who underwent AHSCT for MDS in six institutions from Argentina.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>A retrospective analysis of 54 AHSCT was carried out in 52 patients (mean age: 9 years; range: 2\u201319; 35 males).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MDS subtypes were refractory cytopenia of childhood (RCC) (n: 26, 50%), refractory anemia with excess blasts (RAEB) (n: 9, 18%), RAEB in transformation (RAEB\u2010T) (n: 8, 15%) and juvenile myelomonocytic leukemia (JMML) (n: 9, 17%). At time of transplant, seven (13%) patients transformed to acute myeloid leukemia (AML) and two patients with RCC to RAEB. Donors were related in 32 cases (59%) and the stem cells source was: bone marrow (63%), peripheral blood (26%), and umbilical cord blood (11%). Five\u2010year DFS and OS were 50% and 55% respectively; and for patients with JMML, 57% and 67% respectively. Cumulative incidence of NRM and relapse were 27% and 21% respectively. In the multivariate analysis, umbilical cord blood (HR 4.07; <jats:italic>P<\/jats:italic>\u2009=\u20090.025) and age \u2265 9 years at transplantation (HR 3.28; <jats:italic>P<\/jats:italic>\u2009=\u20090.017) were associated with lower OS; age and graft\u2010versus\u2010host disease (GVHD) had a higher NRM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our series, more than half of the patients achieved long term OS with AHSCT. Less toxic conditioning regimens or more intensive GVHD prophylaxis could lead to better results in some children. Pediatr Blood Cancer 2015;62:153\u2013157. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25238","type":"journal-article","created":{"date-parts":[[2014,9,28]],"date-time":"2014-09-28T02:05:38Z","timestamp":1411869938000},"page":"153-157","source":"Crossref","is-referenced-by-count":12,"title":["Allogeneic hematopoietic stem cell transplantation in pediatric myelodysplastic syndromes: A multicenter experience from Argentina"],"prefix":"10.1002","volume":"62","author":[{"given":"Ana L.","family":"Basquiera","sequence":"first","affiliation":[{"name":"Hospital Privado Centro M\u00e9dico de C\u00f3rdoba C\u00f3rdoba Argentina"},{"name":"Instituto Universitario de Ciencias Biom\u00e9dicas de C\u00f3rdoba (IUCBC) C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Pizzi","sequence":"additional","affiliation":[{"name":"Hospital de Pediatr\u00eda SAMIC Prof. Dr. Juan Pedro Garrahan Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agust\u00edn Gonz\u00e1lez","family":"Correas","sequence":"additional","affiliation":[{"name":"Hospital de Pediatr\u00eda SAMIC Prof. Dr. Juan Pedro Garrahan Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo G.","family":"Longo","sequence":"additional","affiliation":[{"name":"Hospital Austral Pilar Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanda C.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os Sor Mar\u00eda Ludovica de La Plata Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda V.","family":"Prates","sequence":"additional","affiliation":[{"name":"Hospital Italiano de La Plata Buenos Aires 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