{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:37:59Z","timestamp":1789882679077,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,4]],"date-time":"2014-10-04T00:00:00Z","timestamp":1412380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Minimally invasive surgery (MIS) is still not a well\u2010accepted surgical approach to remove neuroblastic tumors. We aimed to assess the indications and limits of MIS in this childhood tumor according to tumor location and image\u2010defined risk factors (IDRFs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Between 2006 and 2012, 39 patients underwent MIS for neuroblastic tumors, using thoracoscopic (n\u2009=\u200920), retroperitoneoscopic (n\u2009=\u20091) or laparoscopic approaches (n\u2009=\u200918). The tumor locations were paravertebral (n\u2009=\u200918; thoracic n\u2009=\u200915, lumbar n\u2009=\u20093), perivascular (n\u2009=\u20095; abdominal n\u2009=\u20092; thoracic n\u2009=\u20093), adrenal (n\u2009=\u200913), pleural (n\u2009=\u20092) and pelvic (n\u2009=\u20091). Two patients were treated for relapses. According to the INRG staging system, IDRFs were absent in 20 patients and present in 19 patients. Ten patients received chemotherapy preoperatively. Mean largest diameter was 35\u2009mm for thoracic tumors (range: 7\u201385\u2009mm) and 34\u2009mm for abdominal tumors (range: 10\u201375\u2009mm). Mean follow\u2010up was 25 months (range: 5\u2013116 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Resection was macroscopically incomplete (R2) for six thoracic tumors and one adrenal tumor. Conversion was necessary for three thoracic L2 tumors. Postoperative complications consisted of chylothorax in three patients with L2 paravertebral thoracic tumors, Horner's syndrome in a patient with a cervicothoracic tumor, and renal atrophy in a patient with a L2 abdominal tumor. No perioperative or postoperative complications occurred in patients with adrenal and abdominal paravertebral tumors. The overall survival rate was 98%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In carefully selected cases, MIS permits safe and efficient resection of neuroblastic tumors in children. Open surgical approach should be considered if organ or vascular control or quality of resection is jeopardized. Pediatr Blood Cancer 2015;62:257\u2013261. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25248","type":"journal-article","created":{"date-parts":[[2014,10,5]],"date-time":"2014-10-05T02:23:16Z","timestamp":1412475796000},"page":"257-261","source":"Crossref","is-referenced-by-count":59,"title":["Minimally invasive surgery of neuroblastic tumors in children: Indications depend on anatomical location and image\u2010defined risk factors"],"prefix":"10.1002","volume":"62","author":[{"given":"Sabine","family":"Irtan","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Necker Enfants\u2010Malades Hospital Paris Descartes University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9 J.","family":"Brisse","sequence":"additional","affiliation":[{"name":"Department of Radiology Curie Institute Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Minard\u2010Colin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Gustave Roussy Institute Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Schleiermacher","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Curie Institute Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Canale","sequence":"additional","affiliation":[{"name":"Department of Radiology Gustave Roussy Institute Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Sarnacki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Necker Enfants\u2010Malades Hospital Paris Descartes University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,4]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"758","article-title":"Surgery as the only treatment for INSS stage 2 neuroblastoma: Risk factors predicting relapse","volume":"35","author":"Michon J","year":"2000","journal-title":"Med Ped Oncol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910143411601"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-12064"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.04.069"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9499-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000081415.49550.01"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64896-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2007.06.008"},{"key":"e_1_2_6_10_1","first-page":"vii","article-title":"IPEG guidelines for the surgical treatment of adrenal masses in children","volume":"20","author":"International Pediatric Endosurgery Group","year":"2010","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2007.06.004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2005.15.470"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2005.15.80"},{"key":"e_1_2_6_14_1","first-page":"1087","article-title":"Minimally\u2010invasive surgery in cancer children","volume":"94","author":"Leclair MD","year":"2007","journal-title":"Bull Cancer"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2007.0043"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.05.030"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.04.086"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2010.04.006"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2011.0141"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.6876"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11101352"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2011.08.003"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.03.018"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2006.07.022"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-014-3476-z"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8921"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.05.042"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.03.056"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002470050629"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.07.029"}],"container-title":["Pediatric Blood &amp; 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