{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:56:37Z","timestamp":1776452197303,"version":"3.51.2"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T00:00:00Z","timestamp":1413590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This retrospective review provides preliminary data regarding the safety and efficacy of olanzapine for chemotherapy\u2010induced vomiting (CIV) control in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Children &lt;18 years old who received olanzapine for acute chemotherapy\u2010induced nausea and vomiting (CINV) control from December 2010 to August 2013 at four institutions were identified. Patient characteristics, chemotherapy, antiemetic prophylaxis, olanzapine dosing, CIV control, liver function test results and adverse events were abstracted from the health record. Toxicity was graded using CTCAEv4.03.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty children (median age 13.2 years; range: 3.10\u201317.96) received olanzapine during 158 chemotherapy blocks. Olanzapine was most often (59%) initiated due to a history of poorly controlled CINV. The mean initial olanzapine dose was 0.1\u2009mg\/kg\/dose (range: 0.026\u20130.256). Most children who received olanzapine beginning on the first day of the chemotherapy block experienced complete CIV control throughout the acute phase (83\/128; 65%). There was no association between the olanzapine dose\/kg and complete CIV control (OR 1.01; 95% CI: 0.999\u20131.020; <jats:italic>P<\/jats:italic>\u2009=\u20090.091). Sedation was reported in 7% of chemotherapy blocks and was significantly associated with increasing olanzapine dose (OR: 1.17; 95% CI: 1.08\u20131.27; <jats:italic>P<\/jats:italic>\u2009=\u20090.0001). Of the 25 chemotherapy blocks where ALT and\/or AST were reported more than once, grade 1\u20133 elevations were observed in five. The mean weight change in 31 children who received olanzapine during more than one chemotherapy block was 0% (range: \u221222 to +18).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Olanzapine may be an important option to improve CIV control in children. Prospective controlled evaluation of olanzapine for CINV prophylaxis in children is warranted. Pediatr Blood Cancer 2015;62:496\u2013501. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25286","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T15:09:26Z","timestamp":1413644966000},"page":"496-501","source":"Crossref","is-referenced-by-count":31,"title":["Olanzapine for treatment and prevention of acute chemotherapy\u2010induced vomiting in children: A retrospective, multi\u2010center review"],"prefix":"10.1002","volume":"62","author":[{"given":"Jacqueline","family":"Flank","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Hospital for Sick Children Toronto Canada"},{"name":"Leslie Dan Faculty of Pharmacy University of Toronto Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Thackray","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danelle","family":"Nielson","sequence":"additional","affiliation":[{"name":"Center for Cancer and Blood Disorders Department of Nursing Children's Medical Center Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"August","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Children's Mercy Hospitals and Clinics Kansas City Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal","family":"Schechter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Toronto Toronto Canada"},{"name":"Division of Haematology\/Oncology The Hospital for Sick Children Toronto Canada"},{"name":"Child Health Evaluative Sciences Research Institute The Hospital for Sick Children Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Toronto Toronto Canada"},{"name":"Division of Haematology\/Oncology The Hospital for Sick Children Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillian","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Toronto Toronto Canada"},{"name":"Division of Haematology\/Oncology The Hospital for Sick Children Toronto Canada"},{"name":"Child Health Evaluative Sciences Research Institute The Hospital for Sick Children Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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