{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:33:36Z","timestamp":1789389216521,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T00:00:00Z","timestamp":1415404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Fanconi anemia (FA) predisposes to hematologic disorders and myeloid neoplasia in childhood and to solid cancers, mainly oral carcinomas, in early adulthood. Few cases of solid cancers have been reported in childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>We conducted a national retrospective study of solid tumors occurring in patients registered with or determined to have FA during childhood in France. Phenotypic features, tumor type, cancer treatment, and outcome were analyzed. Whenever available, fresh\u2010frozen tumors were analyzed by microarray\u2010based comparative genomics hybridization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified eight patients with FA with solid tumor from 1986 to 2012. For two patients, the diagnosis of FA was unknown at the time of cancer diagnosis. Moreover, we identified one fetus with a brain tumor. All patients showed failure to thrive and had dysmorphic features and abnormal skin pigmentation. Seven patients had <jats:italic>BRCA2\/FANCD1<\/jats:italic> mutations; five of these featured more than one malignancy and the median age at the time of cancer diagnosis was 11 months (range 0.4\u20133 years). Solid tumor types included five nephroblastomas, two rhabdomyosarcomas, two neuroblastomas, and three brain tumors. Two children died from the toxic effects of chemotherapy, two patients from the cancer, and one patient from secondary leukemia. Only one <jats:italic>BRCA2<\/jats:italic> patient was alive more than 3 years after diagnosis, after tailored chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Solid tumors are rare in FA during childhood, except in patients with <jats:italic>BRCA2\/FANCD1<\/jats:italic> mutations. The proper genetic diagnosis is mandatory to tailor the treatment. Pediatr Blood Cancer 2015;62:463\u2013470. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25303","type":"journal-article","created":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T14:47:59Z","timestamp":1415458079000},"page":"463-470","source":"Crossref","is-referenced-by-count":39,"title":["Fanconi anemia and solid malignancies in childhood: A national retrospective study"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-7768","authenticated-orcid":false,"given":"Aurore","family":"Malric","sequence":"first","affiliation":[{"name":"Department of Pediatrics Curie Institute Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4277-9871","authenticated-orcid":false,"given":"Anne\u2010Sophie","family":"Defachelles","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Centre Oscar Lambret Lille 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