{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:30:49Z","timestamp":1774362649658,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"American Cancer Society Doctoral Degree Scholarship in Cancer Nursing","award":["119073-DSCN-10-090-01-SCN"],"award-info":[{"award-number":["119073-DSCN-10-090-01-SCN"]}]},{"name":"National Cancer Institute - Children's Oncology Group","award":["U10CA098543"],"award-info":[{"award-number":["U10CA098543"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Obesity is a well documented problem associated with childhood acute lymphoblastic leukemia (ALL) with increasing body mass index often observed during therapy. This study aims to evaluate if weight gain, early in therapy, is predictive of obesity at the end of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>In this secondary analysis, data from 1,017 high\u2010risk ALL patients previously treated on a Children's Oncology Group protocol (CCG study 1961) were reviewed. Logistic regression was used to examine whether change in BMI z\u2010score at Induction or Delayed Intensification (DI) 1 were predictive of obesity at the end of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The BMI z\u2010score at the beginning of Induction and the change in BMI z\u2010score during Induction were both significant predictors of obesity at the end of therapy. The change in BMI z\u2010score during cycle 1 of DI was not found to be associated with obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It is well know that obesity at the beginning of therapy is predictive of obesity at the end of ALL therapy. The new, and more important, finding from this study is that even after adjusting for baseline weight, the increase in BMI z\u2010scores during induction was an independent predictor of obesity at the end of therapy. Most researchers agree that prevention is the best form of treatment for obesity as it is difficult to reverse once it is present. This study suggests that monitoring weight trends during Induction may be useful in guiding healthcare practitioners in identifying which patients are at highest risk for obesity development so that early intervention may occur. Pediatr Blood Cancer 2015;62:434\u2013439. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25316","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T20:28:58Z","timestamp":1416342538000},"page":"434-439","source":"Crossref","is-referenced-by-count":64,"title":["Weight change during childhood acute lymphoblastic leukemia induction therapy predicts obesity: A report from the Children's Oncology Group"],"prefix":"10.1002","volume":"62","author":[{"given":"Janice S.","family":"Withycombe","sequence":"first","affiliation":[{"name":"Children's Cancer Center Palmetto Health Columbia South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynette M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Nebraska Medical Center Omaha Nebraska"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane L.","family":"Meza","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Nebraska Medical Center Omaha Nebraska"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie","family":"Merkle","sequence":"additional","affiliation":[{"name":"College of Nursing University of Arizona Tucson Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa Spezia","family":"Faulkner","sequence":"additional","affiliation":[{"name":"Emory School of Nursing Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Ritter","sequence":"additional","affiliation":[{"name":"College of Nursing University of Arizona Tucson Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nita L.","family":"Seibel","sequence":"additional","affiliation":[{"name":"National Cancer Institute Bethesda Maryland"},{"name":"Children's National Medical Center Washington DC Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki","family":"Moore","sequence":"additional","affiliation":[{"name":"College of Nursing University of Arizona Tucson Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,18]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"National Cancer Institute. 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