{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:14:46Z","timestamp":1764587686149},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T00:00:00Z","timestamp":1415404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:label \/><jats:p>Hypereosinophilia is a rare phenomenon associated with childhood malignancy, predominantly acute lymphoblastic leukaemia. Causation is unclear and likely to have multiple mechanisms. We report a six year old boy presenting with hypereosinophilia and associated Loeffler endocarditis. Three months following his initial hypereosinophilia he developed cutaneous B\u2010lymphoblastic lymphoma. Re\u2010analysis of apparently uninvolved bone marrow, taken at initial presentation, revealed a single, previously unidentified, t(5;14)(q31;q32) positive cell. Using fluorescent in situ hybridisation, we demonstrate <jats:italic>IL3\/IgH@<\/jats:italic> fusion in cutaneous lymphoma cells. Our case confirms the association of hypereosinophilia and B\u2010lymphoblastic lymphoma and strengthens the association between IL3 hypersecretion and hypereosinophilia. Pediatr Blood Cancer 2015;62:1055\u20131057. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25318","type":"journal-article","created":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T15:25:29Z","timestamp":1415460329000},"page":"1055-1057","source":"Crossref","is-referenced-by-count":12,"title":["Cutaneous B\u2010lymphoblastic lymphoma with <i>IL3\/IgH<\/i> translocation presenting with hypereosinophilia and acute endocarditis"],"prefix":"10.1002","volume":"62","author":[{"given":"Simon","family":"Bomken","sequence":"first","affiliation":[{"name":"Northern Institute for Cancer Research Newcastle University Newcastle upon Tyne UK"},{"name":"Department of Paediatric Oncology Newcastle upon Tyne NHS Foundation Trust Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun","family":"Haigh","sequence":"additional","affiliation":[{"name":"Northern Genetics Service Newcastle upon Tyne NHS Foundation Trust Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Bown","sequence":"additional","affiliation":[{"name":"Northern Genetics Service Newcastle upon Tyne NHS Foundation Trust Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Carey","sequence":"additional","affiliation":[{"name":"Department of Haematology Newcastle upon Tyne NHS Foundation Trust Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Histopathology Newcastle upon Tyne NHS Foundation Trust Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Windebank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,8]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcpc049009"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025217"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1980.tb07174.x"},{"key":"e_1_2_3_5_1","first-page":"1895","article-title":"A case of hypereosinophilic syndrome associated with childhood ALL","volume":"23","author":"Sato Y","year":"1982","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80180-7"},{"key":"e_1_2_3_7_1","first-page":"382","article-title":"Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: Case report and literature review","volume":"5","author":"Hogan TF","year":"1987","journal-title":"Murgo AJ"},{"key":"e_1_2_3_8_1","first-page":"109","article-title":"Evidence for the clonal nature of hypereosinophilic syndrome","volume":"32","author":"Da Silva MA","year":"1988","journal-title":"Schwenk GR Jr"},{"key":"e_1_2_3_9_1","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1182\/blood.V73.8.2081.2081","article-title":"The t(5;14) translocation in a case of acute lymphocytic leukemia joins the interleukin\u20103 gene to the immunoglobulin heavy chain gene","volume":"73","author":"Grimaldi JC","year":"1989","journal-title":"Blood"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000205289"},{"key":"e_1_2_3_11_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1182\/blood.V76.2.285.285","article-title":"Activation of the IL\u20103 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia","volume":"76","author":"Meeker TC","year":"1990","journal-title":"Blood"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09098.x"},{"key":"e_1_2_3_13_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1182\/blood.V44.4.489.489","article-title":"L\u00f6ffler's endomyocardial fibrosis with eosinophilia in association with acute lymphoblastic leukemia","volume":"44","author":"Blatt PM","year":"1974","journal-title":"Blood"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-008-9360-7"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08103.x"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950120109"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-003-2019-8"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190500508710"},{"key":"e_1_2_3_19_1","first-page":"191","article-title":"Stimulation of human hematopoietic progenitor cell proliferation and differentiation by recombinant human interleukin\u20103. 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