{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:33:44Z","timestamp":1752550424847},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hematologic reference values vary by ethnicity. We aimed to determine reference values of hemoglobin (Hb) for Korean adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using data from the 5th Korean National Health and Nutrition Examination Survey (KNHANES), we obtained reference values for Hb in adolescents aged 10\u201320 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 2,526 subjects recruited, 330 were excluded due to chronic diseases (9 congenital heart disease, 6 epilepsy, and 1 thyroid disease) or abnormal laboratory values (253 subjects with Fe\/TIBC &lt;16%, 103 subjects with MCV &lt;80\u2009fl). Accordingly, data from 2,196 subjects (male\u2009=\u20091,196 and female\u2009=\u20091,000) were analyzed and age\u2010 and gender\u2010stratified means and percentile values of Hb were obtained. Pertinent findings observed in the current study were: (i) Hb levels in Korean male were similar to those of non\u2010Hispanic Caucasians; (ii) Hb values in females were similar to those of non\u2010Hispanic Caucasians until age of 15, and thereafter were slightly lower. Prevalence of anemia according to WHO criteria and our own criteria (Hb levels &lt;2 standard deviations of age\u2010 and gender\u2010specific values) in total sample was 3.5% (88\/2,526) and 3.8% (97\/2,526), respectively. Anemia was more prevalent in female in comparison with male (6.5% vs. 1.0%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results could be used as a national reference standard to correctly classify a large population sample. Further studies are necessary to determine reference Hb values for children younger than 10 years and identify genetic variations associated with distinctive characteristics observed in this study. Pediatr Blood Cancer 2015;62:409\u2013413. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25349","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T22:45:39Z","timestamp":1417560339000},"page":"409-413","source":"Crossref","is-referenced-by-count":3,"title":["The hemoglobin values of Korean adolescents show distinctive characteristics in comparison to those of Caucasians and African Americans"],"prefix":"10.1002","volume":"62","author":[{"given":"Jung Sub","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Pediatrics Korea Cancer Center Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju\u2010Hee","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Korea Cancer Center Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Korea Cancer Center Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Ah","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Korea Cancer Center Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980008002401"},{"key":"e_1_2_5_3_1","volume-title":"Nelson Textbook of Pediatrics","author":"Lerner NB","year":"2011"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80344-3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1984.02140470024008"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/34.9.1694"},{"key":"e_1_2_5_7_1","first-page":"75","article-title":"Hemoglobin and MCV values in 4,074 healthy black children and adolescents","volume":"79","author":"Haddy TB","year":"1987","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20848"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1532\/LH96.04010"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.462"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2010.00836.x"},{"key":"e_1_2_5_12_1","first-page":"673","article-title":"Studies on normal values for red blood cells in Korean children","volume":"39","author":"Kim SK","year":"1996","journal-title":"Korean J Pediatr"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.4082\/kjfm.2013.34.2.79"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.10.021"},{"key":"e_1_2_5_15_1","unstructured":"WHO. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Vitamin and Mineral Nutrition Information System. Geneva: World Health Organization 2011 (WHO\/NMH\/NHD\/MNM\/11.1). (Accessed July 22 2014 athttp:\/\/ www.who.int\/vmnis\/indicators\/haemoglobin.pdf)."},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-3046"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt087"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.467"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.531"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds534"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1109-1161"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25349","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.25349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T07:42:34Z","timestamp":1696491754000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.25349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,2]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1002\/pbc.25349"],"URL":"https:\/\/doi.org\/10.1002\/pbc.25349","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,2]]}}}