{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:59:58Z","timestamp":1767995998023,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T00:00:00Z","timestamp":1421107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>We describe the effect and side effects in two children with cancer treated with intravenous methadone in extreme doses (&gt;10\u2009mg\/kg\/day) due to vincristine\u2010induced neuropathy where surgical procedures provoked severe neuropathic pain. The maximum daily dose was 33 and 25\u2009mg\/kg\/day. Methadone remained effective at adjusted doses. Few side effects were reported. No significant changes in paraclinical data were observed. Prolonged QTc\u2010interval occurred only during concomitant treatment with fluconazole. In conclusion, methadone should be seen as a part of the armamentarium against cancer\u2010related pain. Methadone can be used in extreme doses with appropriate monitoring by clinicians experienced in its use. Pediatr Blood Cancer 2015;62:1087\u20131090. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25392","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T02:39:58Z","timestamp":1421203198000},"page":"1087-1090","source":"Crossref","is-referenced-by-count":22,"title":["Extreme doses of intravenous methadone for severe pain in two children with cancer"],"prefix":"10.1002","volume":"62","author":[{"given":"Vinni Faber","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Department of Pediatrics Aarhus University Hospital Skejby Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicki","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Department of Oncology, the Palliative Team Aarhus University Hospital Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torben Wors\u00f8e","family":"Jespersen","sequence":"additional","affiliation":[{"name":"Department of Oncology, the Palliative Team Aarhus University Hospital Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Hasle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aarhus University Hospital Skejby Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200911020-00004"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/10966210252785097"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2011.0076"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(01)00389-X"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21584"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318279e492"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(98)00366-2"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-199812000-00013"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2013.840568"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-1928-y"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.13.13"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/15360288.2013.786011"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2011.00349.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.48"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2012.04415.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2010.05.005"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2012.11.001"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2012.10.014"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2012.07.031"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25392","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.25392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T07:42:59Z","timestamp":1696491779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.25392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,13]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1002\/pbc.25392"],"URL":"https:\/\/doi.org\/10.1002\/pbc.25392","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,13]]}}}