{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:51:01Z","timestamp":1778575861035,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T00:00:00Z","timestamp":1424304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Supratentorial PNETs (sPNET) are uncommon embryonal malignancies of the central nervous system whose prognosis has historically been poor. We evaluated the outcome and prognostic factors of children with sPNET treated prospectively on a Children's Oncology Group trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Following surgery, patients received craniospinal radiotherapy with concurrent carboplatin followed by six months of maintenance chemotherapy with cyclophosphamide and vincristine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five\u2010year overall survival (OS) and progression\u2010free survival (PFS) for all patients was 58\u2009\u00b1\u20097% and 48\u2009\u00b1\u20097%. For patients with pineoblastoma (n\u2009=\u200923), five\u2010year OS and PFS was 81\u2009\u00b1\u20099% and 62\u2009\u00b1\u200911%. Extent of resection but not M\u2010stage was prognostic. Five\u2010year OS and PFS for 37 patients with non\u2010pineal tumors (NPsPNET) was 44\u2009\u00b1\u20098% and 39\u2009\u00b1\u20098%, significantly worse than for PB (<jats:italic>P<\/jats:italic>\u2009=\u20090.055 and 0.009 respectively). Extent of resection and major radiotherapy deviations were prognostic. Five year OS was 59\u2009+\/\u2212\u200911.4% for those undergoing complete resection versus 10.4\u2009+\/\u2212\u20097% for those who did not (<jats:italic>P\u2009<\/jats:italic>=\u20090.017). Central pathologic review called 14 (38%) \u201cclassic\u201d sPNET, 8 (22%) \u201cundifferentiated\u201d and 13 (35%) \u201cmalignant gliomas.\u201d There was no significant difference between the subgroups, although survival distributions approached significance when the combined \u201cclassic\u201d and \u201cundifferentiated\u201d group was compared to the \u201cmalignant gliomas.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Carboplatin during RT followed by 6 months of non\u2010intensive chemotherapy is a feasible treatment strategy for patients with sPNET. Aggressive surgical resection should be attempted if feasible. The classification of supratentorial small cell malignancies can be difficult. Pediatr Blood Cancer 2015;62:776\u2013783. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25405","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T16:13:08Z","timestamp":1424362388000},"page":"776-783","source":"Crossref","is-referenced-by-count":71,"title":["Outcome and prognostic factors for children with supratentorial primitive neuroectodermal tumors treated with carboplatin during radiotherapy: A report from the Children's Oncology Group"],"prefix":"10.1002","volume":"62","author":[{"given":"Regina I.","family":"Jakacki","sequence":"first","affiliation":[{"name":"AstraZeneca One Medimmune Way Gaithersburg Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Pathology Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Kocak","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine University of Tennessee Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Boyett","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Goldwein","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Perelman Center for Advanced Medicine Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minesh","family":"Mehta","sequence":"additional","affiliation":[{"name":"University of Maryland School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger 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