{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:00:19Z","timestamp":1774418419331,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T00:00:00Z","timestamp":1423267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We sought to determine whether survivors of standard risk ALL (SR\u2010ALL) treated without cranial radiation have increased risk for obesity by assessing changes in body mass index (BMI) during and after treatment; identifying contributing patient and treatment factors; comparing rates of overweight\/obese to national health data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Eligibility for this retrospective cohort study included: (i) previous enrollment on legacy therapy trials CCG1922 or CCG1952; (ii) continuous first remission; and (iii) age at follow\u2010up evaluation of 6\u201316.99 years. Height and weight from diagnosis, consolidation, start of maintenance, last cycle of maintenance, and off\u2010therapy were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 269 subjects were a median age of 3.5 years at diagnosis and 13.3 years at follow\u2010up. BMI% significantly increased from induction to consolidation (+17.6\u2009\u00b1\u20091.6%), start of maintenance to end\u2010of\u2010treatment (+3.3\u2009\u00b1\u20091.6%) and decreased from end\u2010of\u2010treatment to follow\u2010up (\u22123.5\u2009\u00b1\u20091.6%,). Higher BMI% at follow\u2010up was associated with higher BMI% at diagnosis (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), but not age at diagnosis, gender, or race. Patients previously randomized to dexamethasone had a stronger association between BMI% at diagnosis and BMI% at follow\u2010up than those who received prednisone (<jats:italic>P<\/jats:italic>\u2009=\u20090.0005). At follow\u2010up, 39% of survivors were overweight or obese; the relative risk of overweight\/obese was 1.028 (<jats:italic>P<\/jats:italic>\u2009=\u20090.738) compared to the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study of patients with SR\u2010ALL found a significant increase in BMI% largely during the first month of therapy that is greater with dexamethasone than prednisone. However, after therapy, there was no increased risk of overweight\/obese BMI compared to non\u2010cancer peers. Pediatr Blood Cancer 2015;62:1035\u20131041. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25411","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T16:07:31Z","timestamp":1423325251000},"page":"1035-1041","source":"Crossref","is-referenced-by-count":37,"title":["Survivors of standard risk acute lymphoblastic leukemia do not have increased risk for overweight and obesity compared to non\u2010cancer peers: A report from the Children's Oncology Group"],"prefix":"10.1002","volume":"62","author":[{"given":"Susan J.","family":"Lindemulder","sequence":"first","affiliation":[{"name":"Oregon Health &amp; Science University Doernbecher Children's Hospital Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda C.","family":"Stork","sequence":"additional","affiliation":[{"name":"Oregon Health &amp; Science University Doernbecher Children's Hospital Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Bostrom","sequence":"additional","affiliation":[{"name":"Children's Hospitals and Clinics of Minnesota Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Lu","sequence":"additional","affiliation":[{"name":"University of Florida Department of Biostatistics Colleges of Medicine, Public Health &amp; Health Profession Gainesville FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenakshi","family":"Devidas","sequence":"additional","affiliation":[{"name":"University of Florida Department of Biostatistics Colleges of Medicine, Public Health &amp; Health Profession Gainesville FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Hunger","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine University of Colorado Cancer Center Children's Hospital Aurora CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph P.","family":"Neglia","sequence":"additional","affiliation":[{"name":"University of Minnesota Medical Center Fairview Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina S.","family":"Kadan\u2010Lottick","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine Yale Cancer Center New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,7]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1663","article-title":"Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: A report from the Children's Oncology Group","volume":"2012","author":"Hunger SP","journal-title":"J Clin Oncol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.11.8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2012.12.014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-911X(200008)35:2<91::AID-MPO1>3.0.CO;2-G"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.06.131"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23050"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.3527"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.8709"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31818c0120"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22782"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23010"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01931"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000100781"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21496"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23251"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.16"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24012"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-186502"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.5408"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2454"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-12-011809"},{"key":"e_1_2_6_23_1","first-page":"2740","article-title":"Oral 6\u2010mercaptopurine versus oral 6\u2010thioguanine and veno\u2010occlusive disease in children with standard\u2010risk acute lymphoblastic leukemia: Report of the Children's Oncology Group CCG\u20101952","volume":"115","author":"Stork LC","year":"2010","journal-title":"Clinical Trial Blood"},{"key":"e_1_2_6_24_1","first-page":"1","article-title":"CDC growth charts for the United States: Methods and development","volume":"11","author":"Kuczmarski RJ","year":"2000","journal-title":"Vital Health Stats"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","unstructured":"National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis evaluation and treatment of high blood pressure in children and adolescents. Pediatrics2004:114(2 suppl 4th Report):555\u2013576.","DOI":"10.1542\/peds.114.2.S2.555"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2329C"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.20.2401"},{"key":"e_1_2_6_28_1","unstructured":"Centers for Disease Control and Prevention. National Health and Nutrition Examination Survey 2005\u20132006 raw data. NHANES 2005\u20132006 home page:http:\/\/www.cdc.gov\/nchs\/nhanes\/nhanes2005\u20132006\/nhanes05_06.htm. Published November 2007 Accessed January 27 2012."},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3332"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.07.043497"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2329C"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-40-6-1073"},{"key":"e_1_2_6_33_1","first-page":"615","article-title":"Clinical pharmacology of the anti\u2010inflammatory steroids","volume":"2","author":"Liddle GW","year":"1962","journal-title":"Clin Pharmacol Ther"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90233-9"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324412"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22964"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2010.23.7.669"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01790.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979883"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25411","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.25411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T07:43:11Z","timestamp":1696491791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.25411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,7]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1002\/pbc.25411"],"URL":"https:\/\/doi.org\/10.1002\/pbc.25411","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,7]]}}}