{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:58:54Z","timestamp":1787875134128,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T00:00:00Z","timestamp":1423872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Fanconi anaemia is a genetic disease characterized by congenital abnormalities, progressive bone marrow failure, and a higher predisposition of oral squamous cell carcinoma. The purpose of this study was to evaluate the prevalence of oral mucosa lesions in patients with Fanconi anaemia without hematopoietic stem cell transplantation (HSCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Patients with Fanconi anaemia who had not undergone HSCT was cross\u2010sectional evaluated for the presence of oral lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sample was composed of 78 male and 60 female patients, with a median age of 9 years. Of the 138 patients, approximately 45% manifested at least one oral mucosa abnormality: 35 patients (25%) presented with traumatic injuries, and 16 (12%) exhibited leukoplakia. The following lesions were observed in low prevalence: aphthous ulcers, atrophic tongue, petechiae and hematomas, gingival hyperplasia, mucoceles, herpes, hyperpigmentation, haemangioma, non\u2010neoplastic proliferative lesions, neutropenic ulcers, papilloma, and candidiasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was a high prevalence of oral leukoplakias in patients with Fanconi anaemia who had not undergone HSCT. It highlights the need of regular oral screenings in this cohort of concern for head and neck malignancies and suggests that oral leukoplakias should be further investigated as part of the syndrome phenotype. Pediatr Blood Cancer 2015;62:1024\u20131026. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25417","type":"journal-article","created":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T22:51:30Z","timestamp":1423954290000},"page":"1024-1026","source":"Crossref","is-referenced-by-count":29,"title":["Oral leukoplakia in patients with Fanconi anaemia without hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"62","author":[{"given":"Laura","family":"Grein Cavalcanti","sequence":"first","affiliation":[{"name":"Universidade Federal do Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine F\u00e1tima","family":"Lyko","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Lins Fuentes","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Miguel","family":"Amen\u00e1bar","sequence":"additional","affiliation":[{"name":"Department of Stomatology Universidade Federal do Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmem","family":"Bonfim","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Service Hospital de Cl\u00ednicas Universidade Federal do Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassius Carvalho","family":"Torres\u2010Pereira","sequence":"additional","affiliation":[{"name":"Department of Stomatology Universidade Federal do Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23954"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2004.00549.x"},{"key":"e_1_2_5_4_1","first-page":"239","article-title":"Squamous cell carcinoma of the tongue due to Fanconi's Anemia after bone marrow transplantation","volume":"25","author":"Pasquini R","year":"2003","journal-title":"Rev Bras Hematol Hemoter"},{"key":"e_1_2_5_5_1","first-page":"248","article-title":"Oral and dental findings in children with Fanconi anemia","volume":"29","author":"Tekcicek M","year":"2007","journal-title":"Pediatr Dent"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010591002413"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2007.1.29"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-160X-2-1"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12058"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1652"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2006.01282.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2013.09.005"},{"key":"e_1_2_5_13_1","first-page":"518","article-title":"Definition of leukoplakia and related lesions. An aid to studies on oral precancer","volume":"4","year":"1978","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2005.00632.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.05.016"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00440.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01712.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2007.01394.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.06.007"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25417","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.25417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T07:42:30Z","timestamp":1696491750000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.25417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,14]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1002\/pbc.25417"],"URL":"https:\/\/doi.org\/10.1002\/pbc.25417","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,14]]}}}