{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:09:32Z","timestamp":1762866572619},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,2,8]],"date-time":"2015-02-08T00:00:00Z","timestamp":1423353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>As the survival of children with cardiac disease increases, chronic complications of deep venous thrombosis from cardiac catheterization, particularly post\u2010thrombotic syndrome, may be important to monitor for and treat, if needed. We aimed to determine the prevalence of this syndrome in children who underwent cardiac catheterization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We conducted a cross\u2010sectional study of children &lt;18 years old at least 1 year from first catheterization through the femoral vein. We used the Manco\u2010Johnson instrument, the only tool validated in children, to diagnose post\u2010thrombotic syndrome. We defined the syndrome as a score \u22651. It was considered physically and functionally significant if the score was \u22651 in both physical and functional domains of the instrument. We also conducted ultrasonography to assess for thrombosis and valvular insufficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 62 children with a median age of 4 months during catheterization and a median of 5.4 years since catheterization. A total of 40 children had post\u2010thrombotic syndrome (prevalence: 64.5%; 95% confidence interval: 51.3\u201376.3%), the majority of which were mild. Presence of cyanotic congenital heart disease, total number of catheterizations, use of antithrombotic agents at any time after the first catheterization, age at first catheterization, or time since first catheterization was not associated with the syndrome. A total of seven children (prevalence: 11.3%; 95% confidence interval: 3.2\u201319.4%) had physically and functionally significant syndrome. None of the children had abnormalities on ultrasonography at the time of enrollment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Post\u2010thrombotic syndrome is a common complication after cardiac catheterization. Manifestations are usually mild and unlikely to require treatment. Pediatr Blood Cancer 2015;62:1222\u20131227. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25438","type":"journal-article","created":{"date-parts":[[2015,2,8]],"date-time":"2015-02-08T16:12:53Z","timestamp":1423411973000},"page":"1222-1227","source":"Crossref","is-referenced-by-count":16,"title":["Prevalence of post\u2010thrombotic syndrome after cardiac catheterization"],"prefix":"10.1002","volume":"62","author":[{"given":"Michael J.","family":"Luceri","sequence":"first","affiliation":[{"name":"Department of Pediatrics Yale School of Medicine New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana A.","family":"Tala","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Yale\u2010New Haven Children's Hospital New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance G.","family":"Weismann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yale School of Medicine New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cicero T.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Yale School of Medicine New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Vincent S.","family":"Faustino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yale School of Medicine New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25550"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198505000-00018"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/028418518702800304"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951102000938"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04539.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002469900151"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70071-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.02901.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.026989"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(11)70024-X"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.127276"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.07.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2308"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2011.30.1.143"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200006000-00013"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32834bdb1c"},{"key":"e_1_2_6_19_1","first-page":"765","article-title":"Characterization of post\u2010thrombotic syndrome in children with congenital heart disease: A comparison of instruments","volume":"9","author":"Brandao LR","year":"2011","journal-title":"J Thromb Haemost"},{"key":"e_1_2_6_20_1","first-page":"CD010196","article-title":"Different unfractionated heparin doses for preventing arterial thrombosis in children undergoing cardiac catheterization","volume":"3","author":"Avila ML","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.09.043"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e318250af0c"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25438","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25438","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.25438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T11:23:21Z","timestamp":1696505001000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.25438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,8]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1002\/pbc.25438"],"URL":"https:\/\/doi.org\/10.1002\/pbc.25438","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,8]]}}}