{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:36:33Z","timestamp":1791272193340,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T00:00:00Z","timestamp":1425254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:label\/><jats:p>Latin Americans are an underappreciated population affected by sickle cell disease (SCD). Sickle trait and SCD exist throughout Latin America and U.S. Latino communities. We describe the epidemiology and genetic heterogeneity of SCD among Latin Americans, and fetal hemoglobin expression. National population\u2010based newborn screening for SCD is limited to Brazil, Costa Rica, and the U.S. Available and extrapolated data suggest that over 6,000 annual births and 100,000\u2013150,000 Latin Americans are affected by SCD. This comprehensive review highlights the substantial numbers and population distribution of SCD and sickle trait in Latin America, and where national newborn screening programs for SCD exist. Pediatr Blood Cancer 2015;62:1131\u20131136. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25450","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T13:49:54Z","timestamp":1425304194000},"page":"1131-1136","source":"Crossref","is-referenced-by-count":28,"title":["Sickle cell in sickle cell disease in Latin America and the United States"],"prefix":"10.1002","volume":"62","author":[{"given":"Alexandra","family":"Huttle","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, Stem Cell Transplantation Department of Pediatrics Columbia University Medical Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys E.","family":"Maestre","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences Cardiovascular Institute Institute for Biological Research University of Zulia, Maracaibo Venezuela, and G.H. Sergievsky Center Columbia University Medical Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Lantigua","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University Medical Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy S.","family":"Green","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, Stem Cell Transplantation Department of Pediatrics Columbia University Medical Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2012.128"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001484"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70150-5"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24711"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21883"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-233700"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24557"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12323"},{"key":"e_1_2_5_10_1","unstructured":"Organization PAH. 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