{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:13:29Z","timestamp":1767651209261},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,3,8]],"date-time":"2015-03-08T00:00:00Z","timestamp":1425772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment intensification was considered a suitable strategy to increase the cure rate of lymphoblastic lymphoma (LBL) in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>The AIEOP LNH\u201097 trial was run between 1997 and 2007 for newly diagnosed LBL in patients aged less than 18 years. Treatment schedule was based on the previous, LSA2\u2010L2 derived, AIEOP LNH\u201092 protocol. Modifications included: increased dose of upfront cyclophosphamide and methotrexate, use of <jats:sc>l<\/jats:sc>\u2010Asparaginase during induction therapy, intensive block therapy for slow responders, and late intensification (\u201cReinduction\u201d) for patients with advanced stage disease. Total therapy duration was 12 months for stage I and II, and 24 months for stage III and IV. Central nervous system prophylaxis did not include cranial irradiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>114 eligible patients were enrolled, 84 males and 30 females; median age was 9 years. Complete remission was obtained in 98% of patients. After a median follow\u2010up time of seven years, 29 patients failed due to progression of disease (n\u2009=\u20092), relapse (n\u2009=\u200925), or second malignancy (n\u2009=\u20092). The 7\u2010year overall survival was 82% (standard error [SE] 4%) and the 7\u2010year event\u2010free survival was 74% (SE 4%). No subgroup showed significantly different event free survival. None of the patients died of front line chemotherapy\u2010related toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment intensification was associated with good outcome in children and adolescents with LBL, with limited toxicity. Prognosis after relapse was better for patients who underwent allogeneic hematopoietic stem cell transplantation. Measurements of biological markers and treatment response are necessary for achieving further improvement through more accurate identification and stratification of patients at risk of disease relapse. Pediatr Blood Cancer 2015;62:1388\u20131394. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25469","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T01:16:53Z","timestamp":1425863813000},"page":"1388-1394","source":"Crossref","is-referenced-by-count":23,"title":["Long\u2010term results of the AIEOP LNH\u201097 protocol for childhood lymphoblastic lymphoma"],"prefix":"10.1002","volume":"62","author":[{"given":"Marta","family":"Pillon","sequence":"first","affiliation":[{"name":"Clinic of Pediatric Hemato\u2010Oncology Department of Women's and Children's Health University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Aric\u00f2","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Provinciale Ragusa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Mussolin","sequence":"additional","affiliation":[{"name":"Istituto di Ricerca Pediatrica Fondazione Citt \u00e0  della Speranza Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Carraro","sequence":"additional","affiliation":[{"name":"Clinic of Pediatric Hemato\u2010Oncology Department of Women's and Children's Health University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentino","family":"Conter","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica Universit\u00e0 degli Studi di Milano\u2010Bicocca Azienda Ospedaliera San Gerardo Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Sala","sequence":"additional","affiliation":[{"name":"Clinica Pediatrica Universit\u00e0 degli Studi di Milano\u2010Bicocca Azienda Ospedaliera San Gerardo Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Buffardi","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Department Santobono\u2010Pausilipon Hospital of Napoli Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Garaventa","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology Istituto Giannina Gaslini Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"D'Angelo","sequence":"additional","affiliation":[{"name":"Department of Oncology Pediatric Hematology and Oncology Unit A.R.N.A.S. Ospedali Civico Di Cristina e Benfratelli Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Lo Nigro","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\u2010Oncology Policlinico di Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Santoro","sequence":"additional","affiliation":[{"name":"Division of Paediatric Haematology\u2010Oncology Department of Pediatrics Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilde","family":"Piglione","sequence":"additional","affiliation":[{"name":"Division of Pediatric Onco\u2010Hematology Regina Margherita Children's Hospital Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Dipartimento di Onco\u2010Ematologia Pediatrica Ospedale Bambino Ges\u00f9 Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulvio","family":"Porta","sequence":"additional","affiliation":[{"name":"Oncology\u2010Haematology and BMT Unit Ospedale dei Bambini Spedali Civili Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Cesaro","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\u2010Oncology Azienda Ospedaliera Universitaria Integrata Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L.","family":"Moleti","sequence":"additional","affiliation":[{"name":"Hematology Department of Cellular Biotechnologies and Hematology Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiorina","family":"Casale","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Service, Pediatric Department, Second University of Napoli Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Mura","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\u2010Oncology Ospedale Pediatrico Microcitemico Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele S. G.","family":"d'Amore","sequence":"additional","affiliation":[{"name":"Department of Pathology San Bortolo Hospital Vicenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Basso","sequence":"additional","affiliation":[{"name":"Clinic of Pediatric Hemato\u2010Oncology Department of Women's and Children's Health University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Rosolen","sequence":"additional","affiliation":[{"name":"Clinic of Pediatric Hemato\u2010Oncology Department of Women's and Children's Health University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","unstructured":"National Cancer Institute sponsored study of classifications of non\u2010Hodgkin's lymphomas: Summary and description of a working formulation for clinical usage. The non\u2010hodgkin's lymphoma pathologic classification project. Cancer. 1982;49:2112\u20132135.","DOI":"10.1002\/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2"},{"key":"e_1_2_5_3_1","volume-title":"Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt221"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11615"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950200204"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.02.011"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.6.1024"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.2.359"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.6.1368"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1182\/blood.V84.9.3122.3122","article-title":"Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients results and AT of the multicenter trial ALL\u2010BFM 86","volume":"84","author":"Reiter A","year":"1994","journal-title":"Blood"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22162"},{"key":"e_1_2_5_13_1","first-page":"416","article-title":"Intensive ALL\u2010type therapy without local radiotherapy provides a 90% event\u2010free survival for children with T\u2010cell lymphoblastic lymphoma: A BFM group report","volume":"95","author":"Reiter A","year":"2000","journal-title":"Blood"},{"key":"e_1_2_5_14_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2009"},{"key":"e_1_2_5_15_1","first-page":"332","article-title":"Classification, staging and end results of treatment in childhood non Hodgkin's lymphoma: Dissimilarities from lymphomas in adults","volume":"7","author":"Murphy SB","year":"1980","journal-title":"Sem Oncol"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/2344317"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24848"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.2707"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07320.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12460"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.09.021"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1483"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.1318"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701824551"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.7661"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25469","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25469","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.25469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T18:17:05Z","timestamp":1694801825000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.25469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,8]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1002\/pbc.25469"],"URL":"https:\/\/doi.org\/10.1002\/pbc.25469","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,8]]}}}