{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:23:35Z","timestamp":1781112215659,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The goal of this study was to describe the incidence, characteristics, and outcomes of secondary malignant neoplasms (SMN) in survivors of Wilms tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>Patients who were 0\u201320 years of age at time of primary diagnosis with Wilms tumor and reported to the Surveillance, Epidemiology, and End Results [SEER] program between 1973 and 2011 were eligible for inclusion in the cohort. We used competing risks methods to estimate the cumulative incidence of SMNs and assess contributing factors for developing SMN. We estimated standardized incidence ratios (SIR), absolute excess risk and overall survival after SMN using standard methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Within the SEER database, 2,851 patients were diagnosed with Wilms tumor as their first malignancy. Of these, 34 patients were reported to have a SMN. Cumulative incidence of for a secondary malignancy was 0.6% (95% confidence interval [95% CI] 0.3\u20131.0%) at 10 years, 1.6% (95% CI 1.0\u20132.3%) at 20 years, and 3.8% (95% CI 2.4\u20135.9%) at 30 years. Median time from primary diagnosis to SMN diagnosis was 12.5 years. SIR for SMN for survivors of Wilms tumor was 3.4 (95% CI 2.2\u20134.9) with an absolute excess risk of 7.6 per 10,000 persons per year. Exposure to radiation did not significantly increase risk for development of second malignancy. Overall survival for patients with SMN was 64.5% at 5 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Survivors of Wilms tumor are at an increased risk of SMN compared to the general population, but the added risk is relatively small compared to other pediatric cancers. Pediatr Blood Cancer 2015;62:1259\u20131264. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25484","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T14:41:30Z","timestamp":1427294490000},"page":"1259-1264","source":"Crossref","is-referenced-by-count":33,"title":["Second malignant neoplasms among children, adolescents and young adults with Wilms tumor"],"prefix":"10.1002","volume":"62","author":[{"given":"Jean S.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pediatrics UCSF Benioff Children's Hospital, University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Padilla","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Pediatric Surgery UCSF Benioff Children's Hospital, University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"DuBois","sequence":"additional","affiliation":[{"name":"Department of Pediatrics UCSF Benioff Children's Hospital, University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris","family":"Oates","sequence":"additional","affiliation":[{"name":"Department of Pediatrics UCSF Benioff Children's Hospital, University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Boscardin","sequence":"additional","affiliation":[{"name":"Department of Biostatistics UCSF Benioff Children's Hospital, University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Goldsby","sequence":"additional","affiliation":[{"name":"Department of Pediatrics UCSF Benioff Children's Hospital, University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.34-7-328"},{"key":"e_1_2_6_3_1","first-page":"809","article-title":"Advances and changes in the treatment of children with nephroblastoma","volume":"21","author":"Pietras W","year":"2012","journal-title":"Adv Clin Exp Med"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.10.012"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.6981"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/80.8.592"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199710)29:4<239::AID-MPO1>3.0.CO;2-N"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23333"},{"key":"e_1_2_6_9_1","unstructured":"St. Jude Children's Research Hospital.The Childhood Cancer Survivor Study: Baseline Data(https:\/\/ccss.stjude.org\/)."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287214528023"},{"key":"e_1_2_6_11_1","unstructured":"Surveillance E and End Results (SEER) Program.SEER*Stat Database: Incidence\u2014SEER 18 Regs Research Data\u2009+\u2009Hurricane Katrina Impacted Louisiana Cases Nov 2013 Sub (1973\u20132011 varying)\u2014Linked To County Attributes\u2014Total U.S. 1969\u20132012 Counties National Cancer Institute DCCPS Surveillance Research Program Surveillance Systems Branch released April 2014 (updated 5\/7\/2014) based on the November 2013 submission."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.10-10-815"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0400400201"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_6_15_1","unstructured":"Surveillance E and End Results (SEER) Program. 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