{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:43:58Z","timestamp":1783183438130,"version":"3.54.6"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>Histiocytic sarcoma (HS) is a rare disease with poor prognosis which may develop subsequent to acute lymphoblastic leukemia (ALL). Here we report two children treated within the AIEOP\u2010BFM ALL 2009 trial: one patient succumbed to fulminant hemophagocytic lymphohistiocytosis triggered by HS during ALL maintenance therapy, the other patient had a smoldering course of HS for over 2 years, and subsequently died after allogeneic stem cell transplantation. In both cases, HS and ALL were clonally related and apparent return of minimal residual disease (MRD) was detected by qPCR in bone marrow. Thus, HS should be considered in ALL when MRD appears to persist or reappear. Pediatr Blood Cancer 2015;62:1656\u20131660. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25523","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T21:08:01Z","timestamp":1428008881000},"page":"1656-1660","source":"Crossref","is-referenced-by-count":18,"title":["Secondary histiocytic sarcoma may cause apparent persistence or recurrence of minimal residual disease in childhood acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"62","author":[{"given":"Julia","family":"Alten","sequence":"first","affiliation":[{"name":"Department of Pediatrics University Medical Center Schleswig\u2010Holstein Campus Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Klapper","sequence":"additional","affiliation":[{"name":"Department of Pathology Lymph Node Registry Kiel Institute of Hematopathology University Hospital Schleswig\u2010Holstein Campus Kiel 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