{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:44:48Z","timestamp":1765485888356},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:00:00Z","timestamp":1427414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hematopoietic stem cell transplantation (HSCT) is the only known curative treatment of malignant infantile osteopetrosis (MIOP). In this study, short\u2010term serial bone surveys were used to assess radiologic evolution of skeletal changes after HSCT in MIOP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Baseline whole\u2010body bone survey was performed in all patients. HSCT was successful in 14 patients (11 with full chimerism, three with mixed chimerism) in whom follow\u2010up bone surveys were carried out at 6 and 12 months after HSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Normal corticomedullary differentiation was evident in five (<jats:italic>P<\/jats:italic>\u2009=\u20090.06) and 12 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.005) patients at 6 and 12 months, respectively. Abnormal endobone appearance in long bones, present in 11 participants at baseline exam, disappeared in eight (<jats:italic>P<\/jats:italic>\u2009=\u20090.008) and all (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) patients at 6 and 12 months, respectively. In 6\u2010month follow\u2010up, rachitic changes significantly disappeared (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) in long bones; however, they were evident in ribs of 12 patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.50). No patient had rickets in ribs or long bones after 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed considerable resolution of MIOP skeletal changes after HSCT in all patients with either full or mixed chimerism. Rachitic changes in long bones, attenuated corticomedullary differentiation, and endobone appearance were the first to resolve. We propose using single long bone plain x\u2010ray to demonstrate short\u2010term skeletal response to HSCT. Pediatr Blood Cancer 2015;62:1645\u20131649. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25524","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T22:29:44Z","timestamp":1427495384000},"page":"1645-1649","source":"Crossref","is-referenced-by-count":14,"title":["Radiologic resolution of malignant infantile osteopetrosis skeletal changes following hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"62","author":[{"given":"Amir Pejman","family":"Hashemi Taheri","sequence":"first","affiliation":[{"name":"Department of Radiology, Shariati hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Reza","family":"Radmard","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shariati hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soheil","family":"Kooraki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shariati hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Behfar","sequence":"additional","affiliation":[{"name":"Hematology\u2010Oncology and Stem Cell Transplantation Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Pak","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shariati hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Ali","family":"Hamidieh","sequence":"additional","affiliation":[{"name":"Hematology\u2010Oncology and Stem Cell Transplantation Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ardeshir","family":"Ghavamzadeh","sequence":"additional","affiliation":[{"name":"Hematology\u2010Oncology and Stem Cell Transplantation Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-008-9196-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-4-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5484.1504"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1542\/peds.93.2.247","article-title":"Autosomal recessive osteopetrosis: Variability of findings at diagnosis and during the natural course","volume":"93","author":"Gerritsen EJA","year":"1994","journal-title":"Pediatrics"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704194"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198003273021301"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701474"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80495-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82004-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-006-0141-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002470100008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00537.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197410000-00001"},{"key":"e_1_2_7_15_1","first-page":"545","article-title":"Chronic cutaneous graft\u2010versus\u2010host disease in man","volume":"91","author":"Shulman HM","year":"1978","journal-title":"Am J Pathol"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.06983.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2009.11.006"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506153322402"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199511000-00013"}],"container-title":["Pediatric Blood &amp; 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