{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:48:59Z","timestamp":1752230939303},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T00:00:00Z","timestamp":1429488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:label \/><jats:p>Marrow ablative chemotherapy (MAC) with autologous hematopoietic stem cell transplantation (HSCT) is limited by poor bone marrow reserve after chemotherapy and\/or radiotherapy, and the extent of bone\/bone marrow disease. We report a child with recurrent metastatic medulloblastoma who received an allogeneic HSCT while in relapse and subsequently achieved radiological resolution of disease and favorable marrow minimal residual disease (MRD) response. Disease recurred intra\u2010cranially at 304 days post\u2010HSCT. Tumor biopsy 488 days post\u2010HSCT showed infiltration with donor lymphocytes demonstrating graft\u2010versus\u2010tumor (GVT) effect. The patient remained alive &gt;2 years post\u2010HSCT. Allogeneic HSCT may be a consideration for high\u2010risk recurrent medulloblastoma. Pediatr Blood Cancer 2015;62:1667\u20131669. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25525","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T10:38:55Z","timestamp":1429526335000},"page":"1667-1669","source":"Crossref","is-referenced-by-count":5,"title":["Graft versus tumor effect in the brain of a child with recurrent metastatic medulloblastoma"],"prefix":"10.1002","volume":"62","author":[{"given":"Hisham","family":"Abdel\u2010Azim","sequence":"first","affiliation":[{"name":"Division of Hematology, Oncology, Blood and Marrow Transplantation Children's Hospital Los Angeles, University of Southern California Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neena","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, Blood and Marrow Transplantation Children's Hospital Los Angeles, University of Southern California Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kris M.","family":"Mahadeo","sequence":"additional","affiliation":[{"name":"Children's Hospital at Montefiore Albert Einstein College of Medicine Bronx New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan L.","family":"Finlay","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and BMT Nationwide Children's Hospital, Ohio State University Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24341"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.11.036"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.05.094"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07886.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.02.013"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.131"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1322"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4309"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1126\/science.1068440","article-title":"Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants","volume":"295","author":"Ruggeri L","year":"2002","journal-title":"Science (New York, NY)"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1720"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23802"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-0038-7"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.4980"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.9.2495"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21064"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.1.210"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701635"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200312000-00016"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-003-0651-z"},{"key":"e_1_2_5_21_1","first-page":"141","article-title":"Mechanisms involved in the antileukemic effect of immunocompetent allogeneic lymphoid cell transfer","volume":"32","author":"Ellman L","year":"1972","journal-title":"Cancer Res"}],"container-title":["Pediatric Blood &amp; 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