{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:25:48Z","timestamp":1789442748128,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T00:00:00Z","timestamp":1431993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Survivors of childhood acute lymphoblastic leukaemia (ALL) treated with haematopoietic stem cell transplantation and total body irradiation (HSCT\/TBI) have a high cardiometabolic risk despite lacking overt clinical obesity. This study characterised body composition using different methodologies and explored associations with reduced insulin sensitivities in a group of ALL survivors treated with\/without HSCT\/TBI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Survivors of childhood ALL treated with HSCT\/TBI (n\u2009=\u200920,10\u2009M) were compared with Chemotherapy\u2010only (n\u2009=\u200931), and an obese non\u2010leukaemic controls (n\u2009=\u200930). All subjects (aged 16\u201326 years) were investigated with: auxology (BMI, waist and hip circumferences), DEXA (total and regional fat, fat\u2010free mass), abdominal MRI (subcutaneous, visceral, intramuscular fat), oral glucose tolerance tests (impaired glucose tolerance or diabetes, insulin sensitivity) and serum adiponectin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HSCT\/TBI Group displayed a higher prevalence of abnormal glucose tolerance (45%); lower insulin sensitivity; lower lean mass with higher prevalence of reduced fat\u2010free mass index (from DEXA); higher visceral and intramuscular, and lower subcutaneous fat on MRI, compared with the Chemotherapy\u2010only and Obese controls. BMI was lowest in HSCT\/TBI Group. Waist\u2010to\u2010hip and android\u2010to\u2010gynoid ratios were similar between HSCT\/TBI and Obese Groups. Insulin sensitivity adjusted for visceral fat mass was lower in the HSCT\/TBI than the Chemotherapy\u2010only and Obese groups. Adiponectin in the HSCT\/TBI Group was lower than the Chemotherapy\u2010only group, and correlated negatively with time post HSCT\/TBI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HSCT\/TBI survivors have an increased risk of abnormal glucose tolerance and reduced insulin sensitivity with reduced subcutaneous and increased visceral fat distribution, increased total fat mass and reduced lean mass. Pediatr Blood Cancer \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25601","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T17:24:40Z","timestamp":1432056280000},"page":"1992-1999","source":"Crossref","is-referenced-by-count":76,"title":["Reduced insulin sensitivity in childhood survivors of haematopoietic stem cell transplantation is associated with lipodystropic and sarcopenic phenotypes"],"prefix":"10.1002","volume":"62","author":[{"given":"Christina","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Paediatric Endocrinology &amp; Diabetes Bristol Royal Hospital for Children Bristol UK"},{"name":"St. Georges Hospital St. Georges Health Care NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manigandan S.","family":"Thyagiarajan","sequence":"additional","affiliation":[{"name":"Department of Paediatric Radiology Birmingham Children's Hospital 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