{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T19:20:24Z","timestamp":1774034424258,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T00:00:00Z","timestamp":1433462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Finnish Cancer Society"},{"name":"Finnish Foundation for Pediatric Research"},{"name":"Sigrid Juselius Foundation"},{"DOI":"10.13039\/100010128","name":"V\u00e4re Foundation for Pediatric Cancer Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010128","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Academy of Finland, Helsinki, Finland."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the study was to evaluate arterial morphology and function in a national cohort of long\u2010term survivors of high\u2010risk neuroblastoma (NBL) treated with high\u2010dose chemotherapy and autologous hematopoietic stem cell transplantation with or without total body irradiation (TBI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Common carotid, femoral, brachial, and radial artery morphology were assessed with very\u2010high\u2010resolution vascular ultrasound (25\u201355\u2009MHz), and carotid artery stiffness and brachial artery flow\u2010mediated dilatation measured with conventional vascular ultrasound in 19 adult or pubertal (age 22.7\u2009\u00b1\u20094.9 years, range 16\u201330) NBL survivors transplanted during 1984\u20131999 at the mean age of 2.5\u2009\u00b1\u20091.0 years. Results were compared with 20 age\u2010 and sex\u2010matched healthy controls. The cardiovascular risk assessment included history, body mass index, fasting plasma lipids, glucose, and 24\u2010h ambulatory blood pressure (BP). The survivors had consistently smaller arterial lumens, increased carotid intima\u2010media thickness (IMT), plaque formation (N\u2009=\u20093), and stiffness, as well as increased radial artery intima thickness (N\u2009=\u20095) compared with the control group. Survivors displayed higher plasma triglyceride and cholesterol levels, and increased heart rate, as well as increased systolic and diastolic BPs. TBI (N\u2009=\u200910) and a low body surface area were independent predictors for decreased arterial lumen size and increased IMT. Three out of five survivors with subclinical intima thickening had arterial plaques. Plaques occurred only among TBI\u2010treated survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term childhood cancer survivors treated with TBI during early childhood display significant signs of premature arterial aging during young adulthood. Pediatr Blood Cancer \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25616","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T15:39:57Z","timestamp":1433518797000},"page":"2000-2006","source":"Crossref","is-referenced-by-count":41,"title":["Radiotherapy\u2010related arterial intima thickening and plaque formation in childhood cancer survivors detected with very\u2010high resolution ultrasound during young adulthood"],"prefix":"10.1002","volume":"62","author":[{"given":"Anu","family":"Vatanen","sequence":"first","affiliation":[{"name":"Division of Hematology\u2013Oncology and Stem Cell Transplantation Children's Hospital, University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisto","family":"Sarkola","sequence":"additional","affiliation":[{"name":"Division of Cardiology Children's Hospital, University of Helsinki and Helsinki University 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