{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T05:19:57Z","timestamp":1770441597420,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T00:00:00Z","timestamp":1442966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001548","name":"Child Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001548","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005111","name":"Rigshospitalet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005111","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pediatric cancer patients requiring radiation therapy (RT) have been routinely assessed and referred to proton therapy (PT) at an external institution. The benefit of the delivered PT compared to the state\u2010of\u2010the\u2010art intensity modulated x\u2010ray RT (XT) at the home institution was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Twenty\u2010four consecutive children referred for PT during 2010\u20132013 for craniospinal (CSI, n\u2009=\u200910), localized intracranial (IC, n\u2009=\u20097), head\/neck (HN, n\u2009=\u20094) or parameningeal (PM, n\u2009=\u20093) lesions were included. The median age was 8 years (2\u201316 years). XT plans were generated for each patient, blinded to the PT delivered. Dosimetry, estimated growth hormone deficiency (GHD), and neurocognitive dysfunction (NCD) risks were compared for PT and XT (Wilcoxon).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PT started (median) 5 weeks (\u00b1\u20091.3 weeks, 95% CI) after referral. For CSI patients, PT was clearly superior to XT plans with median dose reductions for the heart, lungs and thyroid of 17, 2.5 and 18 Gy, respectively (<jats:italic>P\u2009<\/jats:italic>=\u20090.005). The median estimated NCD and GHD risks were 1\u20133 (max 16) and 2 (max 61) percentage points, respectively, lower for PT compared to XT. The median of the mean doses to the brain, cochleae and pituitary gland was lower with PT than XT for the IC, H\/N and PM patients (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.039). For a single IC patient, the dose to hippocampi and optic chiasm was higher for PT compared to XT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PT clearly benefitted the patients studied, except for IC disease where differences between PT and XT were modest, and comparative PT and XT treatment planning is warranted prior to referral. Pediatr Blood Cancer \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25768","type":"journal-article","created":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T15:44:38Z","timestamp":1443023078000},"page":"262-269","source":"Crossref","is-referenced-by-count":18,"title":["A Retrospective Evaluation of the Benefit of Referring Pediatric Cancer Patients to an External Proton Therapy Center"],"prefix":"10.1002","volume":"63","author":[{"given":"Per","family":"Munck af Rosenschold","sequence":"first","affiliation":[{"name":"Department of Oncology Section of Radiotherapy, Rigshospitalet Copenhagen Denmark"},{"name":"Niels Bohr Institute University of Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svend A.","family":"Engelholm","sequence":"additional","affiliation":[{"name":"Department of Oncology Section of Radiotherapy, Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrik N.","family":"Brodin","sequence":"additional","affiliation":[{"name":"Department of Oncology Section of Radiotherapy, Rigshospitalet Copenhagen Denmark"},{"name":"Institute for Onco\u2010Physics Albert Einstein College of Medicine Bronx New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Oncology Section of Radiotherapy, Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Grosshans","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald X.","family":"Zhu","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Palmer","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cody N.","family":"Crawford","sequence":"additional","affiliation":[{"name":"Institute for Onco\u2010Physics Albert Einstein College of Medicine Bronx New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Mahajan","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.1920"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2009.09.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noq104"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21530"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt156"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-4-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos120"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.03.053"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00411-005-0016-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.12.040"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2011.582514"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860500218819"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.06.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.06.008"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.11.006"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/53\/4\/015"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/53\/4\/014"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/58\/11\/3563"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4737870"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3679340"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1568978"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.9453"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000207607"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.11.027"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.11.241"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27536"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28322"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.08.033"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25768","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25768","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.25768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T06:51:13Z","timestamp":1695711073000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.25768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,23]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1002\/pbc.25768"],"URL":"https:\/\/doi.org\/10.1002\/pbc.25768","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,23]]}}}