{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:42:07Z","timestamp":1785307327271,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Blood Cancer"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1002\/pbc.25803","type":"journal-article","created":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T23:14:38Z","timestamp":1445469278000},"page":"406-411","source":"Crossref","is-referenced-by-count":32,"title":["Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia: Japanese Pediatric Leukemia\/Lymphoma Study Group"],"prefix":"10.1002","volume":"63","author":[{"given":"Hidemitsu","family":"Kurosawa","sequence":"first","affiliation":[{"name":"Department of Pediatrics; Dokkyo Medical University School of Medicine; Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Tanizawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; University of Fukui Faculty of Medical Sciences; Fukui Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Tono","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Iwate Prefectural Chube Hospital; Iwate Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Niigata Cancer Center Hospital; Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruko","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Keio University School of Medicine; Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Soma General Hospital; Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Yuza","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology; Tokyo Metropolitan Children's Medical Center; Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Hotta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Japan Community Healthcare Organization Tokuyama Central Hospital; Tokuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Nagoya University Graduate School of Medicine; Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Nagasaki University School of Medicine; Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Kajiwara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Yokohama City University; Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Moriya Saito","sequence":"additional","affiliation":[{"name":"Clinical Research Center; National Hospital Organization Nagoya Medical Center; Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuki","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Developmental Biology; Tokyo Medical and Dental University; Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souichi","family":"Adachi","sequence":"additional","affiliation":[{"name":"Human Health Sciences, Graduate School of Medicine; Kyoto University; Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keizo","family":"Horibe","sequence":"additional","affiliation":[{"name":"Clinical Research Center; National Hospital Organization Nagoya Medical Center; Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Ehime University Graduate School of Medicine; Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Keio University School of Medicine; Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,20]]},"reference":[{"key":"10.1002\/pbc.25803-BIB0001|pbc25803-cit-0001","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s12185-013-1364-2","article-title":"Incidence and survival rates of hematological malignancies in Japanese children and adolescents (2006-2010): Based on registry data from the Japanese Society of Pediatric Hematology","volume":"98","author":"Horibe","year":"2013","journal-title":"Int J Hematol"},{"key":"10.1002\/pbc.25803-BIB0002|pbc25803-cit-0002","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/sj.leu.2402194","article-title":"Clinicopathologic characteristics of leukemia in Japanese children and young adults","volume":"15","author":"Horibe","year":"2001","journal-title":"Leukemia"},{"key":"10.1002\/pbc.25803-BIB0003|pbc25803-cit-0003","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1542\/peds.2004-2473","article-title":"Clinical and biological features at diagnosis in 40 children with chronic myeloid leukemia","volume":"116","author":"Millot","year":"2005","journal-title":"Pediatrics"},{"key":"10.1002\/pbc.25803-BIB0004|pbc25803-cit-0004","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.1182\/blood-2003-04-1010","article-title":"CML French Group. Results of a prospective phase 2 study combining imatinib mesylate and cytarabine for the treatment of Philadelphia-positive patients with chronic myelogenous leukemia in chronic phase","volume":"102","author":"Gardembas","year":"2003","journal-title":"Blood"},{"key":"10.1002\/pbc.25803-BIB0005|pbc25803-cit-0005","first-page":"4064","article-title":"Randomized comparison of interferon-alpha with busulfan and hydroxyurea in chronic myelogenous leukemia","volume":"84","author":"Hehlmann","year":"1994","journal-title":"The German CML Study Group. Blood"},{"key":"10.1002\/pbc.25803-BIB0006|pbc25803-cit-0006","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1056\/NEJMoa011573","article-title":"International STI571 CML Study Group. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia","volume":"346","author":"Kantarjian","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1002\/pbc.25803-BIB0007|pbc25803-cit-0007","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1056\/NEJMoa022457","article-title":"IRIS Investigators. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia","volume":"348","author":"O'Brien","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1002\/pbc.25803-BIB0008|pbc25803-cit-0008","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1365-2141.1997.d01-1982.x","article-title":"Clinical features at diagnosis in 430 patients with chronic myeloid leukaemia seen at a referral centre over a 16-year period","volume":"96","author":"Savage","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1002\/pbc.25803-BIB0009|pbc25803-cit-0009","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1182\/asheducation-2010.1.368","article-title":"Treatment of pediatric chronic myeloid leukemia in the year 2010: Use of tyrosine kinase inhibitors and stem-cell transplantation","volume":"2010","author":"Suttorp","year":"2010","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1002\/pbc.25803-BIB0010|pbc25803-cit-0010","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1182\/blood.V63.5.1230.1230","article-title":"Hyperleukocytosis and leukostasis: Common features of childhood chronic myelogenous leukemia","volume":"63","author":"Rowe","year":"1984","journal-title":"Blood"},{"key":"10.1002\/pbc.25803-BIB0011|pbc25803-cit-0011","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/sj.leu.2402392","article-title":"Transcription-mediated amplification and hybridisation protection assay to determine BCR-ABL transcript levels in patients with chronic myeloid leukaemia","volume":"16","author":"Langabeer","year":"2002","journal-title":"Leukemia"},{"key":"10.1002\/pbc.25803-BIB0012|pbc25803-cit-0012","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1182\/blood-2013-05-501569","article-title":"European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013","volume":"122","author":"Baccarani","year":"2013","journal-title":"Blood"},{"key":"10.1002\/pbc.25803-BIB0013|pbc25803-cit-0013","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00277-002-0576-y","article-title":"Aseptic necrosis of both femoral heads as first symptom of chronic myelogenous leukemia","volume":"82","author":"Kraemer","year":"2003","journal-title":"Ann Hematol"},{"key":"10.1002\/pbc.25803-BIB0014|pbc25803-cit-0014","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/pbc.20211","article-title":"Hearing loss in chronic myeloid leukemia","volume":"45","author":"Naithani","year":"2005","journal-title":"Pediatr Blood Cancer"},{"key":"10.1002\/pbc.25803-BIB0015|pbc25803-cit-0015","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1600-0609.2005.00421.x","article-title":"Grading of symptoms in hyperleukocytic leukaemia: A clinical model for the role of different blast types and promyelocytes in the development of leukostasis syndrome","volume":"74","author":"Novotny","year":"2005","journal-title":"Eur J Haematol"},{"key":"10.1002\/pbc.25803-BIB0016|pbc25803-cit-0016","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2141.2012.09151.x","article-title":"How I manage priapism in chronic myeloid leukaemia patients","volume":"158","author":"Rodgers","year":"2012","journal-title":"Br J Haematol"},{"key":"10.1002\/pbc.25803-BIB0017|pbc25803-cit-0017","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1182\/blood.V63.4.789.789","article-title":"Prognostic discrimination in \u201cgood-risk\u201d chronic granulocytic leukemia","volume":"63","author":"Sokal","year":"1984","journal-title":"Blood"},{"key":"10.1002\/pbc.25803-BIB0018|pbc25803-cit-0018","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1093\/jnci\/90.11.850","article-title":"A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. Writing Committee for the Collaborative CML Prognostic Factors Project Group","volume":"90","author":"Hasford","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/pbc.25803-BIB0019|pbc25803-cit-0019","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1182\/blood-2010-12-319038","article-title":"Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: The EUTOS score","volume":"118","author":"Hasford","year":"2011","journal-title":"Blood"},{"key":"10.1002\/pbc.25803-BIB0020|pbc25803-cit-0020","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1038\/leu.2013.171","article-title":"The EUTOS prognostic score: Review and validation in 1288 patients with CML treated frontline with imatinib","volume":"27","author":"Hoffmann","year":"2013","journal-title":"Leukemia"},{"key":"10.1002\/pbc.25803-BIB0021|pbc25803-cit-0021","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/bjh.12977","article-title":"International BFM Group (iBFM) Study Group Chronic Myeloid Leukaemia Committee. Managing children with chronic myeloid leukaemia (CML): Recommendations for the management of CML in children and young people up to the age of 18 years","volume":"167","author":"la Fuente","year":"2014","journal-title":"Br J Haematol"},{"key":"10.1002\/pbc.25803-BIB0022|pbc25803-cit-0022","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.blre.2012.01.003","article-title":"Hyperleukocytosis, leukostasis and leukapheresis: Practice management","volume":"26","author":"Ganzel","year":"2012","journal-title":"Blood Rev"},{"key":"10.1002\/pbc.25803-BIB0023|pbc25803-cit-0023","first-page":"ECR30","article-title":"Management of life-threatening pulmonary leukostasis with single agent imatinib mesylate during CML myeloid blast crisis","volume":"89","author":"Leis","year":"2004","journal-title":"Haematologica"},{"key":"10.1002\/pbc.25803-BIB0024|pbc25803-cit-0024","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1159\/000073077","article-title":"Ocular involvement in leukemia-A study of 288 cases","volume":"217","author":"Reddy","year":"2003","journal-title":"Ophthalmologica"},{"key":"10.1002\/pbc.25803-BIB0025|pbc25803-cit-0025","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jaapos.2012.04.006","article-title":"Chronic myeloid leukemia presenting with bilateral central retinal vein occlusion and massive retinal infiltrates","volume":"16","author":"Goel","year":"2012","journal-title":"J AAPOS"},{"key":"10.1002\/pbc.25803-BIB0026|pbc25803-cit-0026","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/sj.eye.6701308","article-title":"Ophthalmic manifestations of acute leukaemias: The ophthalmologist's role","volume":"18","author":"Sharma","year":"2004","journal-title":"Eye (Lond)"},{"key":"10.1002\/pbc.25803-BIB0027|pbc25803-cit-0027","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1200\/JCO.2004.01.191","article-title":"Early deaths and treatment-related mortality in children undergoing therapy for acute myeloid leukemia: Analysis of the multicenter clinical trials AML-BFM 93 and AML-BFM 98","volume":"22","author":"Creutzig","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1002\/pbc.25803-BIB0028|pbc25803-cit-0028","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/cncr.23581","article-title":"Clinical and biologic features and treatment outcome of children with newly diagnosed acute myeloid leukemia and hyperleukocytosis","volume":"113","author":"Inaba","year":"2008","journal-title":"Cancer"},{"key":"10.1002\/pbc.25803-BIB0029|pbc25803-cit-0029","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1182\/blood-2014-10-551507","article-title":"How I treat hyperleukocytosis in acute myeloid leukemia","volume":"125","author":"Rollig","year":"2015","journal-title":"Blood"},{"key":"10.1002\/pbc.25803-BIB0030|pbc25803-cit-0030","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1182\/blood-2011-10-380774","article-title":"How I treat childhood CML","volume":"119","author":"Andolina","year":"2012","journal-title":"Blood"},{"key":"10.1002\/pbc.25803-BIB0031|pbc25803-cit-0031","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1097\/01.ju.0000087608.07371.ca","article-title":"Members of the Erectile Dysfunction Guideline Update Panel, American Urological Association. American Urological Association guideline on the management of priapism","volume":"170","author":"Montague","year":"2003","journal-title":"J Urol"}],"container-title":["Pediatric Blood & Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25803","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/pbc.25803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T01:53:46Z","timestamp":1599702826000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/pbc.25803"}},"subtitle":["Leukostasis in Pediatric CML"],"short-title":[],"issued":{"date-parts":[[2015,10,20]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"URL":"https:\/\/doi.org\/10.1002\/pbc.25803","archive":["Portico"],"relation":{},"ISSN":["1545-5009"],"issn-type":[{"value":"1545-5009","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10,20]]}}}