{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T16:40:39Z","timestamp":1761324039503},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>The classic principles put forth by Wilson and Jungner are often applied to determine the suitability of a condition for universal newborn screening. The three cases described here portray the harmful effects of vitamin B<jats:sub>12<\/jats:sub> deficiency in infancy. The challenges and opportunities of early recognition and treatment are highlighted. Screening newborns would allow early detection and prevention of severe neurological damage in vitamin B<jats:sub>12<\/jats:sub>\u2010deficient infants and enable diagnosis of unrecognized maternal pernicious anemia in asymptomatic mothers. However, lack of standardized methodology and screening cutoffs present challenges to the use of current tandem mass spectrometry technologies for screening.<\/jats:p>","DOI":"10.1002\/pbc.25828","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T11:02:42Z","timestamp":1453719762000},"page":"740-742","source":"Crossref","is-referenced-by-count":19,"title":["Vitamin B<sub>12<\/sub> Deficiency in Infancy: The Case for Screening"],"prefix":"10.1002","volume":"63","author":[{"given":"Gurpreet","family":"Singh","sequence":"first","affiliation":[{"name":"Sections of Paediatric Haematology and Paediatric Oncology, Department of Paediatrics Alberta Children's Hospital  Calgary Alberta Canada"},{"name":"Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doan","family":"Le","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Section of Paediatric Haematology, Department of Paediatrics Alberta Children's Hospital  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kareena","family":"Schnabl","sequence":"additional","affiliation":[{"name":"Newborn Screening and Biochemical Genetics Laboratory University of Alberta Hospital  Edmonton Alberta Canada"},{"name":"Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Leaker","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Section of Paediatric Haematology, Department of Paediatrics Alberta Children's Hospital  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MacGregor","family":"Steele","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Section of Paediatric Haematology, Department of Paediatrics Alberta Children's Hospital  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca L.","family":"Sparkes","sequence":"additional","affiliation":[{"name":"Section of Clinical Genetics, Department of Paediatrics Alberta Children's Hospital  Calgary Alberta Canada"},{"name":"Department of Medical Genetics, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S117"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.112160"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2009.12.003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24784"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.1997.00205.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.03.006"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2014.08.020"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12292"},{"key":"e_1_2_6_10_1","first-page":"206","article-title":"Canadian Paediatric Society; Nutrition and Gastroenterology Committee. 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