{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:50:10Z","timestamp":1780512610320,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T00:00:00Z","timestamp":1449014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>Medulloblastoma is the most common pediatric brain tumor. We describe a child with tuberous sclerosis complex that developed a Group 3, myc overexpressed, metastatic medulloblastoma (MB). Considering the high risk of treatment\u2010induced malignancies, a tailored therapy, omitting radiation, was given. Based on the evidence of mammalian target of rapamycin mTORC, mTOR Complex; RAS, Rat sarcoma; RAF, rapidly accelerated fibrosarcoma (mTOR) pathway activation in the tumor, targeted therapy was applied resulting in complete remission of disease. Although the PI3K\/AKT\/mTOR signaling pathway plays a role in MB, we did not find TSC1\/TSC2 (TSC, tuberous sclerosis complex) mutation in our patient. We speculate that a different pathway resulting in mTOR activation is the basis of both TSC and MB in this child; H&amp;E, haematoxilin and eosin; Gd, gadolinium.<\/jats:p>","DOI":"10.1002\/pbc.25851","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T07:41:36Z","timestamp":1449042096000},"page":"719-722","source":"Crossref","is-referenced-by-count":8,"title":["Metastatic Group 3 Medulloblastoma in a Patient With Tuberous Sclerosis Complex: Case Description and Molecular Characterization of the Tumor"],"prefix":"10.1002","volume":"63","author":[{"given":"Romina","family":"Moavero","sequence":"first","affiliation":[{"name":"Neuroscience and Neurorehabilitation Department Neurology Unit Bambino Ges\u00f9 Children's Hospital,  IRCCS  Rome Italy"},{"name":"Systems Medicine Department Child Neurology and Psychiatry Unit Tor Vergata University Hospital of Rome  Rome 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