{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:42:19Z","timestamp":1762875739629},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T00:00:00Z","timestamp":1450915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Discontinuation of <jats:italic>E. coli<\/jats:italic> <jats:sc>l<\/jats:sc>\u2010asparaginase in patients with acute lymphoblastic leukemia (ALL) is unavoidable upon severe allergic reaction. We sought to examine outcomes following <jats:italic>E. coli<\/jats:italic> <jats:sc>l<\/jats:sc>\u2010asparaginase discontinuation due to severe allergic reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We evaluated the outcome of children enrolled in Taiwan Pediatric Oncology Group\u20102002\u2010ALL protocol between 2002 and 2012, who had <jats:italic>E. coli<\/jats:italic>\n<jats:sc>l<\/jats:sc>\u2010asparaginase discontinued due to severe allergic reactions, and compared the outcomes of those who continued with Erwinia <jats:sc>l<\/jats:sc>\u2010asparaginase (Erwinase) with those who did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 700 patients enrolled in this study, 33 patients had <jats:italic>E. coli<\/jats:italic>\n<jats:sc>l<\/jats:sc>\u2010asparaginase treatment discontinued due to severe allergic reactions. Five\u2010year overall survival did not differ significantly among the 648 patients without discontinuation (81 \u00b1 1.6%, mean \u00b1 SE), compared to 17 patients with allergic reactions and treated with Erwinase (88 \u00b1 7.8%) and 16 patients with allergic reactions but not treated with Erwinase (87 \u00b1 8.6%). Among 16 patients who did not receive Erwinase, all 10 who received \u226550% of the scheduled doses of <jats:italic>E. coli<\/jats:italic>\n<jats:sc>l<\/jats:sc>\u2010asparaginase before discontinuation survived without events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Erwinase treatment may not be needed for some ALL patients with severe allergy to <jats:italic>E. coli<\/jats:italic>\n<jats:sc>l<\/jats:sc>\u2010asparaginase if \u226550% of prescribed doses were received and\/or therapy is augmented with other agents.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25869","type":"journal-article","created":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T15:25:52Z","timestamp":1450970752000},"page":"665-670","source":"Crossref","is-referenced-by-count":12,"title":["Outcomes Following Discontinuation of <i>E. coli<\/i><scp>l<\/scp>\u2010Asparaginase Upon Severe Allergic Reactions in Children With Acute Lymphoblastic 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