{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:53:21Z","timestamp":1777704801684,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T00:00:00Z","timestamp":1452038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Thrasher Research Fund Early Career Award","award":["T32 HL007574"],"award-info":[{"award-number":["T32 HL007574"]}]},{"name":"Thrasher Research Fund Early Career Award","award":["NIH T32 HL007574"],"award-info":[{"award-number":["NIH T32 HL007574"]}]},{"name":"the Association of Public Health Laboratories"},{"name":"the Sickle Cell Foundation of Ghana"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In malaria\u2010endemic countries in West Africa, sickle cell disease (SCD) contributes to childhood mortality. Historically, Liberia had regions wherein hemoglobin S and beta\u2010thalassemia trait were mutually exclusive. Data on hemoglobinopathies in the Monrovia, the capital, are outdated and do not reflect urban migration. Updating the epidemiology of SCD is necessary to plan a public health and clinical agenda. Neither newborn screening (NBS) nor screening tools were available in country. This pilot study aimed to determine the feasibility of NBS using a South\u2013South partnership and define the incidence of sickle cell trait (SCT) and SCD in Monrovia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>This descriptive epidemiologic feasibility study collected dried blood spots from 2,785 consecutive newborns delivered at a hospital in Monrovia. Samples were analyzed by isoelectric focusing at a regional reference laboratory. Infants with SCD were referred for preventive care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SCT occurred in 10.31% of infants screened. SCD occurred in 33 infants screened [1.19% (95% confidence interval [CI]: 0.79\u20131.59%)] (FS: 28\/33, FSB: 2\/33, FSA: 2\/33, FSX: 1\/33). There were no infants with FSC phenotype observed. Nonsickling hemoglobin phenotypes \u201cFC\u201d and \u201cF\u201d were each present in three infants screened. Seventy\u2010six percent of infants with SCD were brought to care, demonstrating the feasibility of our approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of SCD and other hemoglobinopathies remains high in Liberia. Additional studies are needed to clarify sickle genotypes and identify the contribution of silent beta\u2010thalassemia alleles. By developing regional partnerships, countries similar to Liberia can acquire current data to inform NBS as an important public health initiative toward improving child health.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.25875","type":"journal-article","created":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T12:32:27Z","timestamp":1452169947000},"page":"671-676","source":"Crossref","is-referenced-by-count":52,"title":["Newborn Screening for Sickle Cell Disease in Liberia: A Pilot Study"],"prefix":"10.1002","volume":"63","author":[{"given":"Ven\u00e9e N.","family":"Tubman","sequence":"first","affiliation":[{"name":"Dana\u2010Farber\/Boston Children's Cancer and Blood Disorders Center  Boston Massachusetts"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roseda","family":"Marshall","sequence":"additional","affiliation":[{"name":"John F. Kennedy Hospital  Monrovia Liberia"},{"name":"Department of Pediatrics A. M. Dogliotti College of Medicine  Monrovia Liberia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilhemina","family":"Jallah","sequence":"additional","affiliation":[{"name":"Hope for Women's Health  Monrovia Liberia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongjing","family":"Guo","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber\/Boston Children's Cancer and Blood Disorders Center  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clement","family":"Ma","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber\/Boston Children's Cancer and Blood Disorders Center  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwaku","family":"Ohene\u2010Frempong","sequence":"additional","affiliation":[{"name":"Division of Hematology Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy B.","family":"London","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber\/Boston Children's Cancer and Blood Disorders Center  Boston Massachusetts"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew M.","family":"Heeney","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber\/Boston Children's Cancer and Blood Disorders Center  Boston Massachusetts"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,6]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.Sickle cell anaemia: Report by the Secretariat Fifty\u2010ninth World Health Assembly WHA59.20. 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