{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:34:03Z","timestamp":1787654043397,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T00:00:00Z","timestamp":1452556800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T00:00:00Z","timestamp":1452556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Blood Cancer"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1002\/pbc.25896","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T14:27:02Z","timestamp":1452608822000},"page":"818-824","source":"Crossref","is-referenced-by-count":17,"title":["Systemic Chemotherapy and White Matter Integrity in Tracts Associated with Cognition Among Children With Neurofibromatosis Type 1"],"prefix":"10.1002","volume":"63","author":[{"given":"Peter Matthew Kennedy","family":"de Blank","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology and Oncology; Department of Pediatrics, Rainbow Babies and Children's Hospital; Case Western Reserve University; Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey I.","family":"Berman","sequence":"additional","affiliation":[{"name":"Department of Radiology; The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania; Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Jay","family":"Fisher","sequence":"additional","affiliation":[{"name":"Division of Oncology; Department of Pediatrics; The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania; Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,12]]},"reference":[{"key":"10.1002\/pbc.25896-BIB0001|pbc25896-cit-0001","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1037\/a0016674","article-title":"Neurocognitive status in long-term survivors of childhood CNS malignancies: A report from the Childhood Cancer Survivor Study","volume":"23","author":"Ellenberg","year":"2009","journal-title":"Neuropsychology"},{"key":"10.1002\/pbc.25896-BIB0002|pbc25896-cit-0002","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1200\/JCO.2003.01.202","article-title":"Long-term neurologic and neurosensory sequelae in adult survivors of a childhood brain tumor: Childhood cancer survivor study","volume":"21","author":"Packer","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1002\/pbc.25896-BIB0003|pbc25896-cit-0003","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/cncr.11095","article-title":"Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood cancer survivor study","volume":"97","author":"Gurney","year":"2003","journal-title":"Cancer"},{"key":"10.1002\/pbc.25896-BIB0004|pbc25896-cit-0004","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1200\/JCO.2008.21.1433","article-title":"Psychological status in childhood cancer survivors: A report from the childhood cancer survivor study","volume":"27","author":"Zeltzer","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1002\/pbc.25896-BIB0005|pbc25896-cit-0005","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1212\/01.wnl.0000179303.72345.ce","article-title":"The nature and frequency of cognitive deficits in children with neurofibromatosis type 1","volume":"65","author":"Hyman","year":"2005","journal-title":"Neurology"},{"key":"10.1002\/pbc.25896-BIB0006|pbc25896-cit-0006","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/sj.bjc.6603227","article-title":"A prospective study of neurofibromatosis type 1 cancer incidence in the UK","volume":"95","author":"Walker","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1002\/pbc.25896-BIB0007|pbc25896-cit-0007","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1200\/JCO.2011.36.6054","article-title":"Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: A report from the Children's Oncology Group","volume":"30","author":"Ater","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1002\/pbc.25896-BIB0008|pbc25896-cit-0008","first-page":"451","article-title":"Abstracts from the thirteenth international symposium on pediatric neuro-oncology: Results of COG protocol A9952-A randomized phase 3 study of two chemotherapy regimens for incompletely resected low-grade glioma in young children","volume":"10","author":"Ater","year":"2008","journal-title":"Neuro Oncol"},{"key":"10.1002\/pbc.25896-BIB0009|pbc25896-cit-0009","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.neuron.2006.08.012","article-title":"Principles of diffusion tensor imaging and its applications to basic neuroscience research","volume":"51","author":"Mori","year":"2006","journal-title":"Neuron"},{"key":"10.1002\/pbc.25896-BIB0010|pbc25896-cit-0010","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1016\/j.neuroimage.2011.03.065","article-title":"Cerebello-thalamo-cerebral connections in pediatric brain tumor patients: Impact on working memory","volume":"56","author":"Law","year":"2011","journal-title":"NeuroImage"},{"key":"10.1002\/pbc.25896-BIB0011|pbc25896-cit-0011","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1200\/JCO.2005.02.4505","article-title":"White matter anisotropy in post-treatment childhood cancer survivors: Preliminary evidence of association with neurocognitive function","volume":"24","author":"Khong","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1002\/pbc.25896-BIB0012|pbc25896-cit-0012","first-page":"734","article-title":"Diffusion-tensor imaging for the detection and quantification of treatment-induced white matter injury in children with medulloblastoma: A pilot study","volume":"24","author":"Khong","year":"2003","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1002\/pbc.25896-BIB0013|pbc25896-cit-0013","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/neuonc\/nos154","article-title":"White matter integrity is associated with cognitive processing in patients treated for a posterior fossa brain tumor","volume":"14","author":"Palmer","year":"2012","journal-title":"Neuro Oncol"},{"issue":"Suppl 4","key":"10.1002\/pbc.25896-BIB0014|pbc25896-cit-0014","doi-asserted-by":"crossref","first-page":"iv25","DOI":"10.1093\/neuonc\/nos214","article-title":"Cerebral white matter integrity and executive function in adult survivors of childhood medulloblastoma","volume":"14","author":"Brinkman","year":"2012","journal-title":"Neuro Oncol"},{"key":"10.1002\/pbc.25896-BIB0015|pbc25896-cit-0015","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1215\/15228517-2006-002","article-title":"Diffusion tensor imaging of white matter after cranial radiation in children for medulloblastoma: Correlation with IQ","volume":"8","author":"Mabbott","year":"2006","journal-title":"Neuro Oncol"},{"key":"10.1002\/pbc.25896-BIB0016|pbc25896-cit-0016","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/neuonc\/nou306","article-title":"White matter compromise predicts poor intellectual outcome in survivors of pediatric low-grade glioma","volume":"17","author":"Liu","year":"2015","journal-title":"Neuro Oncol"},{"key":"10.1002\/pbc.25896-BIB0017|pbc25896-cit-0017","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.ijrobp.2008.08.060","article-title":"White matter fractional anisotropy correlates with speed of processing and motor speed in young childhood cancer survivors","volume":"74","author":"Aukema","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1002\/pbc.25896-BIB0018|pbc25896-cit-0018","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.ijrobp.2009.02.054","article-title":"Differences in supratentorial damage of white matter in pediatric survivors of posterior fossa tumors with and without adjuvant treatment as detected by magnetic resonance diffusion tensor imaging","volume":"76","author":"Rueckriegel","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1002\/pbc.25896-BIB0019|pbc25896-cit-0019","doi-asserted-by":"crossref","first-page":"e57768","DOI":"10.1371\/journal.pone.0057768","article-title":"Regional variation in brain white matter diffusion index changes following chemoradiotherapy: A prospective study using tract-based spatial statistics","volume":"8","author":"Chapman","year":"2013","journal-title":"PLoS One"},{"key":"10.1002\/pbc.25896-BIB0020|pbc25896-cit-0020","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1037\/a0013927","article-title":"Cognitive control in adolescents with neurofibromatosis type 1","volume":"23","author":"Rowbotham","year":"2009","journal-title":"Neuropsychology"},{"key":"10.1002\/pbc.25896-BIB0021|pbc25896-cit-0021","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/dmcn.12361","article-title":"Relationship between cognitive dysfunction, gait, and motor impairment in children and adolescents with neurofibromatosis type 1","volume":"56","author":"Champion","year":"2014","journal-title":"Dev Med Child Neurol"},{"key":"10.1002\/pbc.25896-BIB0022|pbc25896-cit-0022","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1093\/neuonc\/not068","article-title":"Fractional anisotropy of the optic radiations is associated with visual acuity loss in optic pathway gliomas of neurofibromatosis type 1","volume":"15","author":"Blank","year":"2013","journal-title":"Neuro Oncol"},{"key":"10.1002\/pbc.25896-BIB0023|pbc25896-cit-0023","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/neuonc\/nos076","article-title":"Visual outcomes in children with neurofibromatosis type 1-associated optic pathway glioma following chemotherapy: A multicenter retrospective analysis","volume":"14","author":"Fisher","year":"2012","journal-title":"Neuro Oncol"},{"key":"10.1002\/pbc.25896-BIB0024|pbc25896-cit-0024","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1001\/archneurpsyc.1942.02290060069004","article-title":"An encephalographic ratio for estimating ventricular enlargement and cerebral atrophy","volume":"47","author":"Evans","year":"1942","journal-title":"Arch Neurol Psychiatry"},{"key":"10.1002\/pbc.25896-BIB0025|pbc25896-cit-0025","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/mrm.10609","article-title":"Characterization and propagation of uncertainty in diffusion-weighted MR imaging","volume":"50","author":"Behrens","year":"2003","journal-title":"Magn Reson Med"},{"key":"10.1002\/pbc.25896-BIB0026|pbc25896-cit-0026","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nn1075","article-title":"Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging","volume":"6","author":"Behrens","year":"2003","journal-title":"Nat Neurosci"},{"key":"10.1002\/pbc.25896-BIB0027|pbc25896-cit-0027","first-page":"2200","article-title":"Evaluation of treatment-induced cerebral white matter injury by using diffusion-tensor MR imaging: Initial experience","volume":"26","author":"Kitahara","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1002\/pbc.25896-BIB0028|pbc25896-cit-0028","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1007\/s00330-008-1038-2","article-title":"Voxel-based morphometry and diffusion-tensor MR imaging of the brain in long-term survivors of childhood leukemia","volume":"18","author":"Porto","year":"2008","journal-title":"Eur Radiol"},{"key":"10.1002\/pbc.25896-BIB0029|pbc25896-cit-0029","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s00234-013-1245-7","article-title":"Effects of chemotherapy on the brain in childhood: Diffusion tensor imaging of subtle white matter damage","volume":"55","author":"Morioka","year":"2013","journal-title":"Neuroradiology"},{"key":"10.1002\/pbc.25896-BIB0030|pbc25896-cit-0030","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1200\/JCO.2012.46.7050","article-title":"Accelerated aging, decreased white matter integrity, and associated neuropsychological dysfunction 25 years after pediatric lymphoid malignancies","volume":"31","author":"Schuitema","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1002\/pbc.25896-BIB0031|pbc25896-cit-0031","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2214\/AJR.12.9590","article-title":"Diffusion-tensor imaging derived metrics of the corpus callosum in children with neurofibromatosis type I","volume":"200","author":"Filippi","year":"2013","journal-title":"AJR Am J Roentgenol"},{"key":"10.1002\/pbc.25896-BIB0032|pbc25896-cit-0032","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3174\/ajnr.A2005","article-title":"Corpus callosum morphology and microstructure assessed using structural MR imaging and diffusion tensor imaging: Initial findings in adults with neurofibromatosis type 1","volume":"31","author":"Wignall","year":"2010","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1002\/pbc.25896-BIB0033|pbc25896-cit-0033","doi-asserted-by":"crossref","first-page":"e47854","DOI":"10.1371\/journal.pone.0047854","article-title":"Alterations in white matter microstructure in neurofibromatosis-1","volume":"7","author":"Karlsgodt","year":"2012","journal-title":"PLoS One"},{"key":"10.1002\/pbc.25896-BIB0034|pbc25896-cit-0034","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1212\/WNL.54.4.914","article-title":"Brain volume in children with neurofibromatosis type 1: Relation to neuropsychological status","volume":"54","author":"Moore","year":"2000","journal-title":"Neurology"},{"key":"10.1002\/pbc.25896-BIB0035|pbc25896-cit-0035","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1177\/0883073809350723","article-title":"Corpus callosum morphology and its relationship to cognitive function in neurofibromatosis type 1","volume":"25","author":"Pride","year":"2010","journal-title":"J Child Neurol"},{"key":"10.1002\/pbc.25896-BIB0036|pbc25896-cit-0036","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.celrep.2013.08.011","article-title":"Nf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculature","volume":"4","author":"Mayes","year":"2013","journal-title":"Cell Rep"}],"container-title":["Pediatric Blood & Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25896","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25896","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/pbc.25896\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T03:34:18Z","timestamp":1498275258000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1002\/pbc.25896"}},"subtitle":["Chemotherapy and White Matter Integrity in NF1"],"short-title":[],"issued":{"date-parts":[[2016,1,12]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"URL":"https:\/\/doi.org\/10.1002\/pbc.25896","archive":["Portico"],"relation":{},"ISSN":["1545-5009"],"issn-type":[{"value":"1545-5009","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1,12]]}}}