{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:21:51Z","timestamp":1790446911078,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T00:00:00Z","timestamp":1456704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Alex's Lemonade Stand Foundation (WDF)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Anaplastic sarcoma of kidney (ASK) is a rare neoplasm recently associated with DICER1 mutations. We report a child with germline DICER1 mutation who developed ASK in preexisting septated renal cysts, which were likely cystic nephroma. From age 2.5 to 6 years, sonographic imaging illustrated changes in the size and number of renal cysts, followed at age 8.8 years by a mass, pathologically an ASK. Lung cysts resected in infancy were diagnosed retrospectively as pleuropulmonary blastoma. Both tumors had acquired somatic DICER1 mutations. Ultrasonographic evolution of renal cysts to ASK has not previously been documented. Children with both pulmonary and renal cysts are candidates for DICER1 mutation testing.<\/jats:p>","DOI":"10.1002\/pbc.25959","type":"journal-article","created":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T14:26:49Z","timestamp":1456756009000},"page":"1272-1275","source":"Crossref","is-referenced-by-count":42,"title":["Evolution of Renal Cysts to Anaplastic Sarcoma of Kidney in a Child With DICER1 Syndrome"],"prefix":"10.1002","volume":"63","author":[{"given":"Mona Kay","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, Lady Davis Institute, Jewish General Hospital, McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Goudie","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology McGill University Health Center  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"Druker","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology The Hospital for Sick Children Department of Molecular and Medical Genetics University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Thorner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Laboratory Medicine The Hospital for Sick Children Department of Molecular and Medical Genetics University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Traubici","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging The Hospital for Sick Children Department of Molecular and Medical Genetics University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Hospital for Sick Children Department of Molecular and Medical Genetics University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pathology Montreal Children's Hospital McGill University Health Centre  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Weber","sequence":"additional","affiliation":[{"name":"Research Institute of the McGill University Health Centre  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Charles","sequence":"additional","affiliation":[{"name":"Anatomical Pathology Sidra Medical and Research Center  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack R.","family":"Priest","sequence":"additional","affiliation":[{"name":"Minneapolis  Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Robert","family":"Fabian","sequence":"additional","affiliation":[{"name":"Departments of Oncology and Experimental Medicine McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Foulkes","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Lady Davis Institute, Jewish General Hospital, McGill University  Montreal Quebec Canada"},{"name":"Research Institute of the McGill University Health Centre  Montreal Quebec Canada"},{"name":"Program in Cancer Genetics Departments of Oncology and Human Genetics McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,29]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31804d43a4"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.03.008"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.242"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3802"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-15-0460"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.08.068"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185114529562"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25092"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2010.081216"},{"key":"e_1_2_4_11_1","unstructured":"DorosL StewartDR BauerAJ WilliamsG RossiCT CarrA YangJ DehnerLP MessingerY HillDA.DICER1\u2010related disorders. 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