{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:01:39Z","timestamp":1761541299768},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T00:00:00Z","timestamp":1461196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Factor X deficiency (FXD) is a rare bleeding disorder, which can result in severe bleeding symptoms such as intracranial hemorrhage (ICH). The most common bleeding symptoms are epistaxis and gum bleeding. ICH is reported in 9\u201326% of all patients with FXD, mostly during the first month of life. Here, we present a rare case of a male presenting with ICH at the age of 20 months as the first manifestation of FXD. Secondary prophylaxis with factor X substitution once weekly prevented further bleeding.<\/jats:p>","DOI":"10.1002\/pbc.25966","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T14:42:22Z","timestamp":1461249742000},"page":"1300-1304","source":"Crossref","is-referenced-by-count":6,"title":["Intracranial Hemorrhage as the First Manifestation of Severe Congenital Factor X Deficiency in a 20\u2010Month\u2010Old Male: Case Report and Review of the Literature"],"prefix":"10.1002","volume":"63","author":[{"given":"Tamara","family":"Diesch","sequence":"first","affiliation":[{"name":"Division of Paediatric Oncology\/Haematology University Children's Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas Xavier","family":"von der Weid","sequence":"additional","affiliation":[{"name":"Division of Paediatric Oncology\/Haematology University Children's Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Schifferli","sequence":"additional","affiliation":[{"name":"Division of Paediatric Oncology\/Haematology University Children's Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"K\u00fchne","sequence":"additional","affiliation":[{"name":"Division of Paediatric Oncology\/Haematology University Children's Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2013.782380"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-532820"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12137"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01814.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01303.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01856.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02213.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1349221"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01878.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12211"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00944.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90567-3"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1225763"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1544000"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02635.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1985.25185116511.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000305"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-200110000-00007"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(03)00119-0"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01315.x"},{"issue":"6","key":"e_1_2_5_22_1","first-page":"461","article-title":"Dental management of a patient with factor X deficiency","volume":"75","author":"Adewumi A","year":"2009","journal-title":"J Can Dent Assoc"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02545.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000315004"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02591.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.00836.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.08.049"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11746"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12245"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2011.122"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03486.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00806.x"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441870"}],"container-title":["Pediatric Blood &amp; 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