{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:29:50Z","timestamp":1761823790817},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T00:00:00Z","timestamp":1457568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Central nervous system (CNS) involvement in the context of hemophagocytic lymphohistiocytosis (HLH) is not uncommon. Given the immunosuppressive nature of HLH therapy, infectious complications are also seen. We describe a 9\u2010year\u2010old male who developed acute neurological decline secondary to aspergillosis while undergoing HLH therapy. The significant overlap observed in CNS neuroimaging of HLH and aspergillosis and the subtleties that may help differentiate the two are discussed. The importance of obtaining tissue for definitive diagnosis is underscored.<\/jats:p>","DOI":"10.1002\/pbc.25967","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T18:44:02Z","timestamp":1457808242000},"page":"1296-1299","source":"Crossref","is-referenced-by-count":8,"title":["A Diagnostic Dilemma: Similarity of Neuroradiological Findings in Central Nervous System Hemophagocytic Lymphohistiocytosis and Aspergillosis"],"prefix":"10.1002","volume":"63","author":[{"given":"Jessica M.","family":"Foley","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology Oncology and BMT Spectrum Health Helen DeVos Children's Hospital  Grand Rapids Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Borders","sequence":"additional","affiliation":[{"name":"Department of Radiology Spectrum Health  Grand Rapids Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth A.","family":"Kurt","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Oncology and BMT Spectrum Health Helen DeVos Children's Hospital  Grand Rapids Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-356261"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06922.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.3.794"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824f800a"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70196-3"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190802517740"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.292075143"},{"key":"e_1_2_5_9_1","first-page":"1597","article-title":"Disseminated aspergillosis involving the brain: Distribution and imaging characteristics","volume":"20","author":"DeLone DR","year":"1999","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-6111(03)00033-8"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01874.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23405"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.192.3.8058942"},{"key":"e_1_2_5_14_1","first-page":"1312","article-title":"Diffusion\u2010weighted cranial MR imaging findings in a patient with hemophagocytic syndrome","volume":"27","author":"Ozgen B","year":"2006","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_5_15_1","first-page":"1115","article-title":"Diffusion\u2010weighted imaging of fungal cerebral infection","volume":"26","author":"Gaviani P","year":"2005","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-007-0569-z"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.162.1.8273655"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.162.2.8310939"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0548"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00606-12"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.264055152"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25967","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.25967","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.25967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T16:20:53Z","timestamp":1695745253000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.25967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,10]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1002\/pbc.25967"],"URL":"https:\/\/doi.org\/10.1002\/pbc.25967","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,10]]}}}