{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:21:45Z","timestamp":1779258105946,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T00:00:00Z","timestamp":1462838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>Humoral and cellular immunity were studied in 28 children completing conventional treatment of standard\u2010risk (SR) or intermediate\u2010risk (IR) acute lymphoblastic leukemia (ALL). Both na\u00efve and memory B cells were most severely affected and showed slow recovery during the 2\u2010year follow\u2010up, while the T\u2010cell compartment showed only minor changes. Immunoglobulins and IgG subclasses, components, and antibodies against vaccine\u2010preventable diseases were not significantly affected. In conclusion, immune recovery after conventional chemotherapy for SR and IR ALL is marked by B\u2010cell depletion, but otherwise did not show any severe deficiencies in lymphocyte function.<\/jats:p>","DOI":"10.1002\/pbc.26047","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T14:04:58Z","timestamp":1462889098000},"page":"1653-1656","source":"Crossref","is-referenced-by-count":21,"title":["Immunological Reconstitution in Children After Completing Conventional Chemotherapy of Acute Lymphoblastic Leukemia is Marked by Impaired B\u2010cell Compartment"],"prefix":"10.1002","volume":"63","author":[{"given":"Minna","family":"Koskenvuo","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics, Turku University Hospital University of Turku  Turku Finland"},{"name":"Division of Pediatric Hematology and Oncology and Stem Cell Transplantation Department of Pediatrics Children's Hospital University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilse","family":"Ekman","sequence":"additional","affiliation":[{"name":"Immunogenetics Laboratory University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmi","family":"Saha","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics, Turku University Hospital University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellinoora","family":"Salokannel","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics, Turku University Hospital University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaakko","family":"Matom\u00e4ki","sequence":"additional","affiliation":[{"name":"Clinical Research Centre Turku University Hospital  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorma","family":"Ilonen","sequence":"additional","affiliation":[{"name":"Immunogenetics Laboratory University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena","family":"Kainulainen","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics, Turku University Hospital University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Arola","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics Tampere University Hospital  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4ivi Maria","family":"L\u00e4hteenm\u00e4ki","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology Department of Pediatrics, Turku University Hospital University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.10.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08478.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07862.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1082"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920315)69:6<1481::AID-CNCR2820690628>3.0.CO;2-L"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02143.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.816423"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2004.11.016"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/707691"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08522.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/511636"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04206.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2009.05.020"}],"container-title":["Pediatric Blood &amp; 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