{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:27:38Z","timestamp":1758806858857},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T00:00:00Z","timestamp":1462320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>Early T\u2010cell precursor acute lymphoblastic leukemia (ETP\u2010ALL) is a subtype of T\u2010acute lymphoblastic leukemia (T\u2010ALL) arising from a primitive precursor. We present a unique case of an infant with ETP\u2010ALL with a missense <jats:italic>NRAS<\/jats:italic> mutation in codon 61 (c.182A&gt;G, p.Q61R). The patient also had a minor population of non\u2010ETP T\u2010ALL blasts and clinical features typically associated with juvenile myelomonocytic leukemia (JMML), namely, absolute monocytosis, splenomegaly, and elevated hemoglobin F. The treatment was initiated with chemotherapy, followed by cord blood transplantation. The patient achieved remission, but unfortunately died from transplant\u2010related complications. This case highlights an <jats:italic>NRAS<\/jats:italic> mutation in ETP\u2010ALL with JMML\u2010like phenotype.<\/jats:p>","DOI":"10.1002\/pbc.26050","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T18:24:29Z","timestamp":1462386269000},"page":"1667-1670","source":"Crossref","is-referenced-by-count":6,"title":["Early T\u2010Cell Precursor Acute Lymphoblastic Leukemia in an Infant With an <i>NRAS<\/i> Q61R Mutation and Clinical Features of Juvenile Myelomonocytic Leukemia"],"prefix":"10.1002","volume":"63","author":[{"given":"Sunil S.","family":"Raikar","sequence":"first","affiliation":[{"name":"Department of Pediatrics Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta and Emory University  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Scarborough","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of Washington  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himalee","family":"Sabnis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta and Emory University  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Bergsagel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta and Emory University  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of Washington  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd M.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seattle Children's Hospital  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank G.","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta and Emory University  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent L.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of Washington  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia\u00a0T.","family":"Bunting","sequence":"additional","affiliation":[{"name":"Department of Pathology Children's Healthcare of Atlanta and Emory University  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70314-0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3283623c61"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10725"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.08.022"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.70"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-014-0443-x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.5387\/fms.51.67"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3400"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08955.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-012-0224-4"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2013.06.010"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12882"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","unstructured":"WoodBL WinterSS DunsmoreKP DevidasM ChenS AsselinB EsiashviliN LohML WinickNJ CarrollWL RaetzEA HungerSP.T\u2010lymphoblastic leukemia (T\u2010ALL) shows excellent outcome lack of significance of the early thymic precursor (ETP) immunophenotype and validation of the prognostic value of end\u2010induction minimal residual disease (MRD) in Children's Oncology Group (COG) Study AALL0434. 56th American Society of Hematology Annual Meeting and Exposition San Francisco CA December 6\u20139 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