{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T15:29:37Z","timestamp":1747063777255},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T00:00:00Z","timestamp":1467936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epstein\u2013Barr virus\u2010related lymphoproliferative disease (EBV\u2010LPD) rarely occurs in patients with acute lymphoblastic leukemia (ALL), who have not received hematopoietic transplantation. We describe EBV\u2010LPD manifesting as facial lesions in two children with ALL in remission. One patient was a 16\u2010year\u2010old male with T\u2010cell ALL with an EBV\u2010positive angiocentric polymorphous lip lesion presenting as right\u2010sided facial swelling. The other patient was a 12\u2010year\u2010old male with B\u2010cell ALL with an EBV\u2010positive polymorphous lymphoplasmacytic infiltrate presenting as bilateral dacryoadenitis. Neither patient had known primary immunodeficiencies. Both cases improved with immunosuppressant de\u2010escalation. These cases suggest that immunosuppression induced by maintenance chemotherapy is sufficient to promote EBV\u2010LPD.<\/jats:p>","DOI":"10.1002\/pbc.26102","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T15:56:45Z","timestamp":1467993405000},"page":"2042-2045","source":"Crossref","is-referenced-by-count":7,"title":["Facial manifestations of Epstein\u2013Barr virus\u2010related lymphoproliferative disease in childhood acute lymphoblastic leukemia in remission: Two atypical presentations"],"prefix":"10.1002","volume":"63","author":[{"given":"Benjamin Y.","family":"Lu","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology &amp; Oncology Massachusetts General Hospital for Children Harvard Medical School  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Kojima","sequence":"additional","affiliation":[{"name":"Center for Transplantation Sciences Massachusetts General Hospital Harvard Medical School  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary S.","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology &amp; Oncology Massachusetts General Hospital for Children Harvard Medical School  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison M.","family":"Friedmann","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology &amp; Oncology Massachusetts General Hospital for Children Harvard Medical School  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith A.","family":"Ferry","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital Harvard Medical School  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard J.","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology &amp; Oncology Massachusetts General Hospital for Children Harvard Medical School  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,8]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"4280","article-title":"Fatal Epstein\u2013Barr virus infection in a child with acute lymphoblastic leukemia in remission","volume":"41","author":"Look AT","year":"1981","journal-title":"Cancer Res"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80362-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198710013171407"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.3.378"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1182\/blood.V81.1.264.264","article-title":"Epstein\u2013Barr virus associated B\u2010cell lymphoproliferation in an infant treated for acute lymphoblastic leukemia","volume":"81","author":"Rohrlich P","year":"1993","journal-title":"Blood"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199701000-00012"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00709.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199906)32:6<447::AID-MPO12>3.0.CO;2-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200003000-00017"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702727"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-911X(20010201)36:2<329::AID-MPO1077>3.0.CO;2-F"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.10466"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.022475"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjh.2011.0047"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cf8622"},{"key":"e_1_2_6_17_1","unstructured":"SS Gaulard P NL Harris ES Jaffe 2008 350 351"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03060150077029"}],"container-title":["Pediatric Blood &amp; 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