{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T14:44:36Z","timestamp":1766760276243},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T00:00:00Z","timestamp":1468454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Council for Science and Technology CONACyT","award":["Salud 2013-01-20211"],"award-info":[{"award-number":["Salud 2013-01-20211"]}]},{"name":"Federal Funding for Research","award":["SME\/MDCB\/058\/2012"],"award-info":[{"award-number":["SME\/MDCB\/058\/2012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Signal transducer and activator of transcription 3 (STAT3) deficiency is a primary immunodeficiency characterized by eczema, complicated recurrent infections, elevated serum immunoglobulin E (IgE), osteopenia, and minimal trauma fractures. Zoledronic acid (ZA) is a long\u2010acting bisphosphonate that has been successfully used in children with secondary osteoporosis and osteogenesis imperfecta. We describe the case of a 7\u2010year\u2010old male with STAT3 deficiency and minimal trauma fractures, who also developed osteonecrosis of the hip. He responded well to intravenous ZA every 6 months for 18 months. Three years later, he walks independently and unaided, and has not suffered any other fractures. Although more studies are needed, ZA might help reduce minimal trauma fractures in patients with STAT3 deficiency.<\/jats:p>","DOI":"10.1002\/pbc.26119","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T13:52:16Z","timestamp":1468504336000},"page":"2054-2057","source":"Crossref","is-referenced-by-count":9,"title":["Zoledronate as effective treatment for minimal trauma fractures in a child with STAT3 deficiency and osteonecrosis of the hip"],"prefix":"10.1002","volume":"63","author":[{"given":"Aid\u00e9 Tamara","family":"Staines Boone","sequence":"first","affiliation":[{"name":"Clinical Immunology Department, Hospital de Especialidades Mexican Social Security Institute (IMSS)  Monterrey Nuevo Le\u00f3n Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio C\u00e9sar","family":"Alc\u00e1ntara\u2010Montiel","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedicine Center for Research and Advanced Studies (CINVESTAV), National Polytechnic Institute (IPN)  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz Mar\u00eda","family":"S\u00e1nchez\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital de Especialidades Mexican Social Security Institute (IMSS)  Monterrey Nuevo Le\u00f3n Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Arce\u2010Cano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital de Especialidades Mexican Social Security Institute (IMSS)  Monterrey Nuevo Le\u00f3n Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Garc\u00eda\u2010Campos","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital de Especialidades Mexican Social Security Institute (IMSS)  Monterrey Nuevo Le\u00f3n Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sa\u00fal Oswaldo","family":"Lugo Reyes","sequence":"additional","affiliation":[{"name":"Immunodeficiencies Research Unit National Institute of Pediatrics (INP)  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4161\/jkst.23435"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31825f95b9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.07.031"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354303"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/302547"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.07.001"},{"key":"e_1_2_7_8_1","first-page":"164","article-title":"Zoledronic acid (zoledronate) in children with osteogenesis imperfecta","volume":"151","author":"Sanchez\u2010Sanchez LM","year":"2015","journal-title":"Gac Med Mex."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-013-9982-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.3.346-a"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354303"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24563"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3317-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4065\/83.9.1032"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.09.068"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23267"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2011.04.027"}],"container-title":["Pediatric Blood &amp; 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