{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T07:31:36Z","timestamp":1782804696694,"version":"3.54.5"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T00:00:00Z","timestamp":1469664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Von Willebrand disease (VWD) is the most common inherited bleeding disorder, affecting one in 1,000 people. Type 2b VWD is a less common subtype caused by a gain\u2010of\u2010function mutation in von Willebrand factor (VWF) that leads to the formation of large, ineffective VWF\u2010platelet multimers in circulation. This unique pathophysiology creates diagnostic and treatment dilemmas. There is limited information on the management of type 2b VWD in the neonatal period. This report describes the management of a neonate with type 2b VWD with an emphasis on the added benefit of concomitant platelet transfusion and factor replacement therapy over factor replacement therapy alone.<\/jats:p>","DOI":"10.1002\/pbc.26168","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T16:09:27Z","timestamp":1469722167000},"page":"103-105","source":"Crossref","is-referenced-by-count":9,"title":["Management of type 2b von Willebrand disease in the neonatal period"],"prefix":"10.1002","volume":"64","author":[{"given":"Lindsay","family":"Proud","sequence":"first","affiliation":[{"name":"Pediatrics Residency Program Children's Hospital of Pittsburgh of UPMC  Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Kim","family":"Ritchey","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Children's Hospital of Pittsburgh of UPMC  Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,28]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"2069","volume-title":"Williams Hematology","author":"Lichtman MA","year":"2010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2003.00523.x"},{"issue":"2","key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1055\/s-0037-1614447","article-title":"Post\u2010DDAVP thrombocytopenia in type 2B von Willebrand disease is not associated with platelet consumption: Failure to demonstrate glycocalicin increase or platelet activation","volume":"81","author":"Casonato A","year":"1999","journal-title":"Thromb Haemost"},{"key":"e_1_2_7_5_1","first-page":"s9","article-title":"Treatment of von Willebrand disease with FVIII\/VWF concentrates","volume":"9","author":"Castaman G","year":"2011","journal-title":"Blood Transfus"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.106764"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2003.00712.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-165233"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115123"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-152280"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.26168","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.26168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T20:55:40Z","timestamp":1695761740000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.26168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,28]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1002\/pbc.26168"],"URL":"https:\/\/doi.org\/10.1002\/pbc.26168","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,28]]}}}