{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:00:21Z","timestamp":1777694421999,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T00:00:00Z","timestamp":1474243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cholelithiasis is a frequent complication in pediatric sickle cell disease (SCD). Though it is standard practice to perform a cholecystectomy in pediatric SCD patients with symptoms of cholelithiasis, the use of elective cholecystectomy for asymptomatic patients remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Records of 191 pediatric sickle cell patients with cholelithiasis who underwent cholecystectomy were retrospectively reviewed. Patients classified as follows: (i) <jats:italic>elective<\/jats:italic>\u2014no preoperative symptoms, cholelithiasis on screening ultrasound, comprehensive preoperative plan; (ii) <jats:italic>symptomatic<\/jats:italic>\u2014preoperative symptoms of cholelithiasis on diagnostic ultrasound, comprehensive preoperative plan; or (iii) <jats:italic>emergent<\/jats:italic>\u2014hospitalization for acute cholecystitis symptoms, cholelithiasis on diagnostic ultrasound, limited preoperative preparation. We compared the morbidity of cholecystectomy by examining pre\u2010 and post\u2010cholecystectomy hospital admission days, length of stay for cholecystectomy, and surgical complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with SCD underwent a total of 191 cholecystectomies over a 10\u2010year period: 51 elective, 110 symptomatic, and 30 emergent. Patients who required emergent cholecystectomy had a longer postoperative hospitalization time than elective or symptomatic cholecystectomy (7.3 vs 4.3, <jats:italic>P<\/jats:italic> &lt; 0.001). Baseline values for total bilirubin and aspartate aminotransferase (AST) were significantly elevated (<jats:italic>P<\/jats:italic> &lt; 0.02 and <jats:italic>P<\/jats:italic> &lt; 0.07, respectively) in patients requiring emergent cholecystectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This represents the largest reported retrospective review of pediatric cholelithiasis and cholecystectomy in SCD to date. These data strongly suggest that elective cholecystectomy decreases morbidity associated with emergent cholecystectomy. The overall outcomes for symptomatic and elective patients are favorable. However, our study indicates the need for prospective studies to identify clinical indicators for those emergent patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.26179","type":"journal-article","created":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T17:16:55Z","timestamp":1474305415000},"page":"113-120","source":"Crossref","is-referenced-by-count":22,"title":["Elective cholecystectomy reduces morbidity of cholelithiasis in pediatric sickle cell disease"],"prefix":"10.1002","volume":"64","author":[{"given":"Emily F.","family":"Goodwin","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige I.","family":"Partain","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D.","family":"Lebensburger","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi S.","family":"Fineberg","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Howard","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1542\/peds.58.2.252","article-title":"Cholecystitis and cholelithiasis masking as abdominal crises in sickle cell disease","volume":"58","author":"Ariyan 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