{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:41:46Z","timestamp":1760550106191},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T00:00:00Z","timestamp":1471996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Refractory\/relapsed Langerhans cell histiocytosis (LCH) has a difficult course with a guarded prognosis. We used a novel protocol including six cycles of pulse dexamethasone and lenalidomide in four children with LCH refractory to first\u2010line agents and courses of cladribine and cytarabine or single\u2010agent cladribine. All four children completed the protocol without any significant adverse effects and remain in complete and durable remission 15\u201318 months posttreatment. The novel protocol we propose for relapsed\/refractory LCH is cost\u2010effective and outpatient\u2010based with durable remission and minimal toxicity. This is particularly suited for resource\u2010limited settings.<\/jats:p>","DOI":"10.1002\/pbc.26199","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T06:32:42Z","timestamp":1472020362000},"page":"110-112","source":"Crossref","is-referenced-by-count":5,"title":["Excellent remission rates with limited toxicity in relapsed\/refractory Langerhans cell histiocytosis with pulse dexamethasone and lenalidomide in children"],"prefix":"10.1002","volume":"64","author":[{"given":"Ramya","family":"Uppuluri","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology Oncology and BMT Apollo Speciality Hospital  Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sreejith","family":"Ramachandrakurup","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Oncology and BMT Apollo Speciality Hospital  Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Subburaj","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Oncology and BMT Apollo Speciality Hospital  Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atish","family":"Bakane","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Oncology and BMT Apollo Speciality Hospital  Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Revathi","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Oncology and BMT Apollo Speciality Hospital  Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.144527"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21504"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-03-635151"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-199211000-00021"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950210406"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199911)33:5<476::AID-MPO7>3.0.CO;2-Q"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000165001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.0736"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-446286"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26104"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-556407"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20578"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1993.tb02262.x"},{"issue":"21","key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1182\/blood.V122.21.2.2","article-title":"Initial phase 3 results of the FIRST (frontline investigation of lenalidomide + dexamethasone versus standard thalidomide) trial (MM\u2010020\/IFM 07 01) in newly diagnosed multiple myeloma (NDMM) patients (Pts) ineligible for stem cell transplantation (SCT)","volume":"122","author":"Facon T","year":"2013","journal-title":"Blood"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"abstract e16555","DOI":"10.1200\/jco.2013.31.15_suppl.e16555","article-title":"Treatment of recurrent Langerhans cell histiocytosis of the vulva with lenalidomide","volume":"31","author":"Ibrahim FI","year":"2013","journal-title":"J Clin Oncol"},{"issue":"11","key":"e_1_2_6_18_1","first-page":"856","article-title":"The effect of lenalidomide on rare blood disorders: Langerhans cell histiocytosis, multicentric Castleman disease, POEMS syndrome, Erdheim\u2013Chester disease and angiomatosis","volume":"58","author":"Adam Z","year":"2012","journal-title":"Vnitr Lek"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2011.631581"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpbc.26199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.26199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T20:55:45Z","timestamp":1695761745000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.26199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,24]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1002\/pbc.26199"],"URL":"https:\/\/doi.org\/10.1002\/pbc.26199","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,24]]}}}